PMID- 24938237
OWN - NLM
STAT- MEDLINE
DCOM- 20140717
LR  - 20151119
IS  - 0041-4131 (Print)
IS  - 0041-4131 (Linking)
VI  - 92
IP  - 2
DP  - 2014 Feb
TI  - [Evaluation of fibrinolysis with streptokinase in ST-elevation myocardial 
      infarction admitted to emergency department].
PG  - 147-53
AB  - BACKGROUND: Fibrinolysis during ST elevation myocardial infarction (STEMI) is 
      feasible in the emergency departments (ED), and this reduces the delay from first 
      medical contact to coronary reperfusion. The aim of the study is to: 1) Evaluate 
      fibrinolysis with streptokinase (SK) in STEMI admitted to the ED. 2) identify 
      clinical criteria predictive of fibrinolysis success. METHODS: prospective study 
      (July 2008-March 2012). Inclusion of STEMI thrombolysed by SK. Fibrinolysis 
      success was defined according to clinical and Electrocardiogram criteria. 
      Multivariate study is used to identify the factors associated with thrombolysis 
      success. RESULTS: Out of the 329 STEMI enrolled during the study period, 224 
      (68%) were thrombolysed. Mean age = 57 +/- 11 years (20-86 years) sex ratio = 6. 
      The average time chest pain - emergency admission was 195 +/- 177 min (15 min to 12 
      hours). The 2/3 of patients had consulted during the first 3 hours. The average 
      success rate of thrombolysis was 59% and reached 83% the first hour, 66% the 
      second hour and 58.7% the third hour. In multivariate analysis, the three 
      independent predictors factors of a fibrinolysis success were: active smoking, 
      current treatment with beta blockers and the delay from onset chest pain to the 
      ED visit less than 180 min. Conversely, diabetes was associated with fibrinolysis 
      failure. Fibrinolysis got complicated by two intracerebral hemorrhages. Three 
      patients had died in the ED. CONCLUSION: Two thirds of patients with STEMI have 
      consulted 3 h after onset of chest pain. Fibrinolysis with streptokinase was 
      effective in 59% of cases.
FAU - Bouhajja, Bechir
AU  - Bouhajja B
FAU - Souissi, Sami
AU  - Souissi S
FAU - Ghazali, Hanene
AU  - Ghazali H
FAU - Yahmadi, Anouar
AU  - Yahmadi A
FAU - Mougaida, Moez
AU  - Mougaida M
FAU - Laamouri, Noura
AU  - Laamouri N
FAU - Sellami, Ali
AU  - Sellami A
FAU - Chkir, Mahbouba
AU  - Chkir M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Evaluation de la fibrinolyse par la streptokinase dans l'infarctus du myocarde 
      avec sus decalage du segment ST admis aux urgences.
PL  - Tunisia
TA  - Tunis Med
JT  - La Tunisie medicale
JID - 0413766
RN  - 0 (Fibrinolytic Agents)
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Electrocardiography
MH  - Emergency Service, Hospital
MH  - Female
MH  - Fibrin Clot Lysis Time/*methods
MH  - *Fibrinolysis
MH  - *Fibrinolytic Agents
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*diagnosis
MH  - Patient Admission
MH  - Prognosis
MH  - *Streptokinase
MH  - Young Adult
EDAT- 2014/06/19 06:00
MHDA- 2014/07/18 06:00
CRDT- 2014/06/19 06:00
PHST- 2014/06/19 06:00 [entrez]
PHST- 2014/06/19 06:00 [pubmed]
PHST- 2014/07/18 06:00 [medline]
AID - /article-medicale-tunisie.php?article=2479 [pii]
PST - ppublish
SO  - Tunis Med. 2014 Feb;92(2):147-53.