PMID- 24938775
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20191027
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 13
IP  - 4
DP  - 2014
TI  - Effect of glatiramer acetate on peripheral blood brain-derived neurotrophic 
      factor and phosphorylated TrkB levels in relapsing-remitting multiple sclerosis.
PG  - 647-51
AB  - Glatiramer acetate (GA) is one of the most widely used disease-modifying drugs 
      for the treatment of relapsing-remitting multiple sclerosis; is assumed to have 
      inductor effects on neurotrophic factor expression. One of these neurotrophic 
      factor systems is the brain-derived neurotrophic factor (BDNF)/receptor tyrosine 
      kinase B (TrkB) pathway. Peripheral blood is thought to contain soluble BDNF, and 
      some blood cells express TrkB. We attempted to determine whether GA treatment 
      leads to changes in plasma BDNF levels and TrkB activation. Such a phenomenon are 
      relapsing-remitting multiple sclerosis patients is significantly reduced; GA 
      treatment is not influencing peripheral BDNF levels, after one year of sustained 
      therapy, not from the point of view of total free BDNF nor the phosphorylated 
      TrkB.
FAU - Vacaras, Vitalie
AU  - Vacaras V
FAU - Major, Zsigmond Z
AU  - Major ZZ
FAU - Muresanu, Dafin F
AU  - Muresanu DF
FAU - Krausz, Tibor L
AU  - Krausz TL
FAU - Marginean, Ioan
AU  - Marginean I
FAU - Buzoianu, Dana A
AU  - Buzoianu DA
AD  - Department of Clinical Neurosciences, University of Medicine and Pharmacy "Iuliu 
      Hatieganu", Victor Babes Street No. 8, 400012 Cluj-Napoca, Romania. 
      dafinm@ssnn.ro.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Peptides)
RN  - 5M691HL4BO (Glatiramer Acetate)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Adult
MH  - Blood Chemical Analysis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glatiramer Acetate
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - Multiple Sclerosis, Relapsing-Remitting/*blood/*drug therapy
MH  - Peptides/*therapeutic use
MH  - Phosphorylation/drug effects
MH  - Protein-Tyrosine Kinases/*blood
MH  - Receptor, trkB
MH  - Time Factors
EDAT- 2014/06/19 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/06/19 06:00
PHST- 2013/04/18 00:00 [received]
PHST- 2013/10/16 00:00 [revised]
PHST- 2013/10/20 00:00 [accepted]
PHST- 2014/06/19 06:00 [entrez]
PHST- 2014/06/19 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - CNSNDDT-EPUB-61030 [pii]
AID - 10.2174/1871527313666140618110049 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2014;13(4):647-51. doi: 
      10.2174/1871527313666140618110049.