PMID- 24941993
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20150115
IS  - 1937-335X (Electronic)
IS  - 1937-3341 (Linking)
VI  - 21
IP  - 1-2
DP  - 2015 Jan
TI  - Nerve regeneration and functional recovery by collagen-binding brain-derived 
      neurotrophic factor in an intracerebral hemorrhage model.
PG  - 62-74
LID - 10.1089/ten.TEA.2014.0139 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) exerts therapeutic effects following 
      intracerebral hemorrhage (ICH). However, it is difficult to maintain sufficient 
      concentrations in the hemorrhage hemisphere. We demonstrated previously that BDNF 
      fused to a collagen-binding domain (CBD) could bind to collagen in the 
      ventricular ependyma and stimulate cell proliferation in the subventricular zone 
      (SVZ). In this study, we verified the therapeutic effects of CBD-BDNF in the rat 
      ICH model induced by bacterial collagenase by injecting CBD-BDNF into the lateral 
      ventricle of ICH rats. The results demonstrated that CBD-BDNF was retained at 
      high levels in the hemorrhage hemisphere, where it promoted neural regeneration 
      and angiogenesis, reduced tissue loss, and improved functional recovery.
FAU - Guan, Jian
AU  - Guan J
AD  - 1 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College , Beijing, People's 
      Republic of China .
FAU - Zhang, Bo
AU  - Zhang B
FAU - Zhang, Jin
AU  - Zhang J
FAU - Ding, Wenyong
AU  - Ding W
FAU - Xiao, Zhifeng
AU  - Xiao Z
FAU - Zhu, Zhaohui
AU  - Zhu Z
FAU - Han, Qianqian
AU  - Han Q
FAU - Wu, Chenxi
AU  - Wu C
FAU - Sun, Yi
AU  - Sun Y
FAU - Tong, Weimin
AU  - Tong W
FAU - Dai, Jianwu
AU  - Dai J
FAU - Wang, Renzhi
AU  - Wang R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140912
PL  - United States
TA  - Tissue Eng Part A
JT  - Tissue engineering. Part A
JID - 101466659
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 9007-34-5 (Collagen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain/blood supply/metabolism/pathology
MH  - Brain Edema/complications/drug therapy/pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*therapeutic use
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cerebral Hemorrhage/complications/*drug therapy/pathology/*physiopathology
MH  - Collagen/*metabolism
MH  - Disease Models, Animal
MH  - Glucose/metabolism
MH  - Hematoma/complications/drug therapy/pathology/physiopathology
MH  - Hemodynamics/drug effects
MH  - Immunohistochemistry
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neovascularization, Physiologic/drug effects
MH  - *Nerve Regeneration/drug effects
MH  - Neurogenesis/drug effects
MH  - Positron-Emission Tomography
MH  - Protein Binding/drug effects
MH  - Rats, Sprague-Dawley
MH  - Recombinant Fusion Proteins/pharmacology/*therapeutic use
MH  - *Recovery of Function/drug effects
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2014/06/20 06:00
MHDA- 2015/09/17 06:00
CRDT- 2014/06/20 06:00
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
AID - 10.1089/ten.TEA.2014.0139 [doi]
PST - ppublish
SO  - Tissue Eng Part A. 2015 Jan;21(1-2):62-74. doi: 10.1089/ten.TEA.2014.0139. Epub 
      2014 Sep 12.