PMID- 24942240
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20191210
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 69
IP  - 4
DP  - 2014
TI  - Urinary brain-derived neurotrophic factor as a biomarker of executive 
      functioning.
PG  - 227-34
LID - 10.1159/000362242 [doi]
AB  - BACKGROUND/AIMS: Neurotrophins such as brain-derived neurotrophic factor (BDNF) 
      are vital for neuronal survival and adaptive plasticity. With high BDNF gene 
      expression in the prefrontal cortex, BDNF is a potential regulatory factor for 
      building and maintaining cognitive reserves. Recent studies suggest that 
      individual differences in executive functioning, a broad cognitive domain reliant 
      upon frontal lobe structure and function, are governed in part by variance in 
      BDNF polymorphisms. However, as neurogenetic data are not necessarily indicative 
      of in vivo neurochemistry, this study examines the relationship between executive 
      functioning and the neurotransmitter by measuring peripheral BDNF levels. 
      METHODS: Fifty-two healthy young adults completed a battery of standardized 
      executive function tests. BDNF levels, adjusted for creatinine, were quantified 
      with enzyme-linked immunosorbent assay of urine samples taken at the time of 
      testing. RESULTS: BDNF concentration was positively associated with cognitive 
      flexibility but had no relationship with working memory, abstract 
      reasoning/planning, self-monitoring/response inhibition, or fluency. CONCLUSIONS: 
      These results individuate cognitive flexibility as the specific facet of 
      executive functioning associated with in vivo BDNF levels. This study also 
      validates urinary BDNF as a peripheral biomarker of cognition in healthy adults.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Koven, Nancy S
AU  - Koven NS
AD  - Program in Neuroscience, Department of Psychology, Bates College, Lewiston, 
      Maine, USA.
FAU - Collins, Larisa R
AU  - Collins LR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140618
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Biomarkers/urine
MH  - Brain-Derived Neurotrophic Factor/*urine
MH  - Cognition/physiology
MH  - Creatinine/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Inhibition, Psychological
MH  - Language
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Neuropsychological Tests
MH  - Thinking/physiology
MH  - Young Adult
EDAT- 2014/06/20 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/06/20 06:00
PHST- 2013/09/19 00:00 [received]
PHST- 2014/03/17 00:00 [accepted]
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 000362242 [pii]
AID - 10.1159/000362242 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2014;69(4):227-34. doi: 10.1159/000362242. Epub 2014 Jun 18.