PMID- 24942684
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20171116
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 260
IP  - 1
DP  - 2014 Jul
TI  - Intestinal dendritic cells in the regulation of mucosal immunity.
PG  - 86-101
LID - 10.1111/imr.12194 [doi]
AB  - The intestine presents a huge surface area to the outside environment, a property 
      that is of critical importance for its key functions in nutrient digestion, 
      absorption, and waste disposal. As such, the intestine is constantly exposed to 
      dietary and microbial-derived foreign antigens, to which immune cells within the 
      mucosa must suitably respond to maintain intestinal integrity, while also 
      providing the ability to mount effective immune responses to potential pathogens. 
      Dendritic cells (DCs) are sentinel immune cells that play a central role in the 
      initiation and differentiation of adaptive immune responses. In the intestinal 
      mucosa, DCs are located diffusely throughout the intestinal lamina propria, 
      within gut-associated lymphoid tissues, including Peyer's patches and smaller 
      lymphoid aggregates, as well as in intestinal-draining lymph nodes, including 
      mesenteric lymph nodes. The recognition that dietary nutrients and microbial 
      communities in the intestine influence both mucosal and systemic immune cell 
      development and function as well as immune-mediated disease has led to an 
      explosion of literature in mucosal immunology in recent years and a growing 
      interest in the functionality of intestinal DCs. In the current review, we 
      discuss recent findings from our group and others that have provided important 
      insights regarding murine and human intestinal lamina propria DCs and highlighted 
      marked developmental and functional heterogeneity within this compartment. A 
      thorough understanding of the role these subsets play in the regulation of 
      intestinal immune homeostasis and inflammation will help to define novel 
      strategies for the treatment of intestinal pathologies and contribute to improved 
      rational design of mucosal vaccines.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Bekiaris, Vasileios
AU  - Bekiaris V
AD  - Immunology Section, Lund University, Lund, Sweden.
FAU - Persson, Emma K
AU  - Persson EK
FAU - Agace, William W
AU  - Agace WW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Antigens)
RN  - 0 (Antigens, CD)
RN  - 0 (CD11b Antigen)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Transcription Factors)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Antigens, CD/metabolism
MH  - CD11b Antigen/metabolism
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Gene Expression Regulation
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Immunity, Mucosal/*physiology
MH  - Integrin alpha Chains/metabolism
MH  - Intestinal Mucosa/*immunology/*metabolism
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Phenotype
MH  - Stem Cells/cytology/metabolism
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
OTO - NOTNLM
OT  - dendritic cell
OT  - lamina propria
OT  - mucosa
EDAT- 2014/06/20 06:00
MHDA- 2015/01/30 06:00
CRDT- 2014/06/20 06:00
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - 10.1111/imr.12194 [doi]
PST - ppublish
SO  - Immunol Rev. 2014 Jul;260(1):86-101. doi: 10.1111/imr.12194.