PMID- 24942931
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20220310
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1842
IP  - 9
DP  - 2014 Sep
TI  - BDNF impairment is associated with age-related changes in the inner retina and 
      exacerbates experimental glaucoma.
PG  - 1567-78
LID - S0925-4439(14)00154-9 [pii]
LID - 10.1016/j.bbadis.2014.05.026 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) stimulation of its high-affinity 
      receptor TrkB results in activation of pro-survival cell-signalling pathways that 
      can afford neuroprotection to the retina. Reduction in retrograde axonal 
      transport of neurotrophic factors such as BDNF from the brain to the neuronal 
      cell bodies in the retina has been suggested as a critical factor underlying 
      progressive and selective degeneration of ganglion cell layer and optic nerve in 
      glaucoma. We investigated the role of BDNF in preserving inner retinal 
      homeostasis in normal and glaucoma states using BDNF(+/-) mice and compared it 
      with wild type controls. This study demonstrated that BDNF(+/-) animals were more 
      susceptible to functional, morphological and molecular degenerative changes in 
      the inner retina caused by age as well as upon exposure to experimental glaucoma 
      caused by increased intraocular pressure. Glaucoma induced a down regulation of 
      BDNF/TrkB signalling and an increase in levels of neurotoxic amyloid beta 1-42 in 
      the optic nerve head which were exacerbated in BDNF(+/-) mice. Similar results 
      were obtained upon analysing the human optic nerve head tissues. Our data 
      highlighted the role of BDNF in maintaining the inner retinal integrity under 
      normal conditions and the detrimental effects of its insufficiency on the retina 
      and optic nerve in glaucoma.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Gupta, Vivek
AU  - Gupta V
AD  - Australian School of Advanced Medicine, Macquarie University, Australia. 
      Electronic address: vivek.gupta@mq.edu.au.
FAU - You, Yuyi
AU  - You Y
AD  - Australian School of Advanced Medicine, Macquarie University, Australia.
FAU - Li, Jonathan
AU  - Li J
AD  - Australian School of Advanced Medicine, Macquarie University, Australia.
FAU - Gupta, Veer
AU  - Gupta V
AD  - School of Medical Sciences, Edith Cowan University, Perth, Australia.
FAU - Golzan, Mojtaba
AU  - Golzan M
AD  - Australian School of Advanced Medicine, Macquarie University, Australia.
FAU - Klistorner, Alexander
AU  - Klistorner A
AD  - Australian School of Advanced Medicine, Macquarie University, Australia; Save 
      Sight Institute, Sydney University, Australia.
FAU - van den Buuse, Maarten
AU  - van den Buuse M
AD  - Behavioural Neuroscience Laboratory, Florey Institute for Neuroscience and Mental 
      Health, Melbourne, Australia; Department of Pharmacology, University of 
      Melbourne, Australia; School of Psychological Science, La Trobe University, 
      Melbourne, Australia.
FAU - Graham, Stuart
AU  - Graham S
AD  - Australian School of Advanced Medicine, Macquarie University, Australia; Save 
      Sight Institute, Sydney University, Australia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140602
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Autopsy
MH  - Axonal Transport
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Case-Control Studies
MH  - *Disease Models, Animal
MH  - Electroretinography
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glaucoma/etiology/metabolism/*pathology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Mice
MH  - Mice, Knockout
MH  - Optic Nerve/metabolism/*pathology
MH  - Peptide Fragments/*metabolism
MH  - Receptor, trkB/metabolism
MH  - Retina/metabolism/*pathology
MH  - Retinal Ganglion Cells/metabolism/*pathology
MH  - Signal Transduction
OTO - NOTNLM
OT  - Amyloid beta
OT  - Brain-derived neurotrophic factor
OT  - Ganglion cell layer
OT  - Glaucoma
OT  - Signal transduction
OT  - TrkB receptor
EDAT- 2014/06/20 06:00
MHDA- 2014/09/26 06:00
CRDT- 2014/06/20 06:00
PHST- 2014/04/03 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
AID - S0925-4439(14)00154-9 [pii]
AID - 10.1016/j.bbadis.2014.05.026 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2014 Sep;1842(9):1567-78. doi: 
      10.1016/j.bbadis.2014.05.026. Epub 2014 Jun 2.