PMID- 24943751
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140619
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 57
IP  - 2
DP  - 2014 Apr-Jun
TI  - Expression of tumor necrosis factor-alpha and nuclear factor-kappaB/RelA and the 
      pathogenesis of psoriasis.
PG  - 205-8
LID - 10.4103/0377-4929.134664 [doi]
AB  - CONTEXT: Tumor necrosis factor-alpha (TNF-alpha) is an important mediator in the 
      pathogenesis of psoriasis. Nuclear factor-kappaB (NF-kappaB) is a transcription 
      factor that regulates the activity of the proinflammatory genes. Psoriasis is an 
      inflammatory disease and the role of TNF-alpha and NF-kappaB, should be considerable. 
      AIMS: We studied the role of TNF-alpha and NF-kappaB in psoriasis. MATERIALS AND METHODS: 
      A total of 61 cases of psoriatic skin biopsies were studies and the grade of 
      TNF-alpha and NF-kappaB, staining was correlated with the histopathological indices of 
      severity. STATISTICAL ANALYSIS USED: Pearson's correlation coefficient and 
      Chi-square test. Statistical Package for Social Sciences version 13 was used. 
      RESULTS: The TNF-alpha immunostain in the cytoplasm of the epidermal cells and basal 
      cells showed a strong inverse correlation with the grade of epidermal hyperplasia 
      (P -0.019 and P -0.009, respectively). The epidermal cytoplasmic positivity and 
      lymphocyte positivity for TNF-alpha did not correlate with the grade of NF-kappaB 
      immunostaining in the epidermal cell nuclei, basal cells or lymphocytes. The 
      basal cell cytoplasmic positivity for TNF-alpha correlated with the grade of NF-kappaB 
      immunostaining in the nucleus of basal cells at a P - 0.005. There was a strong 
      correlation between the epidermal cytoplasmic TNF-alpha immunostaining with the 
      lymphocyte immunostaining (P -0.08); however, there was no correlation between 
      the TNF-alpha expression in the other two locations. CONCLUSIONS: The study outlines 
      the relationship between NF-kappaB and TNF-alpha and their combined role in the 
      development of the characteristic histopathological changes in psoriasis. We 
      hypothesize that NF-kappaB is involved in stimulating the release of TNF-alpha which 
      would account for the characteristic histopathological changes of psoriasis. 
      However, it is likely that NF-kappaB can act independently of TNF-alpha also in the 
      pathogenesis of psoriasis.
FAU - Moorchung, Nikhil
AU  - Moorchung N
AD  - Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
FAU - Vasudevan, Biju
AU  - Vasudevan B
FAU - Mani, N S
AU  - Mani NS
FAU - Verma, Rajesh
AU  - Verma R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
RN  - 0 (Transcription Factor RelA)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Psoriasis/*pathology
MH  - Severity of Illness Index
MH  - Skin/pathology
MH  - Transcription Factor RelA/*biosynthesis
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - Young Adult
EDAT- 2014/06/20 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/06/20 06:00
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - IndianJPatholMicrobiol_2014_57_2_205_134664 [pii]
AID - 10.4103/0377-4929.134664 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2014 Apr-Jun;57(2):205-8. doi: 
      10.4103/0377-4929.134664.