PMID- 24944700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 7
IP  - 4
DP  - 2014 Apr
TI  - Abundant expression of HMGB1 in human T-cell lymphotropic virus type I-infected 
      T-cell lines and high plasma levels of HMGB1 in patients with adult T-cell 
      leukemia.
PG  - 1239-1242
AB  - High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear 
      protein and an extracellular signaling molecule. The concentration of HMGB1 
      protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase 
      chain reaction (PCR), respectively. The present study reports high plasma HMGB1 
      levels in patients with adult T-cell leukemia [ATL; which is caused by infection 
      with human T-cell lymphotropic virus type I (HTLV-I)] compared with normal 
      controls. In addition, HMGB1 was highly expressed in HTLV-I-infected T-cell lines 
      compared with uninfected T-cell lines. The HTLV-I oncoprotein, Tax, induced 
      extracellular release of HMGB1 in T cells. The results suggest that HMGB1 is a 
      potential biomarker and a therapeutic target for ATL.
FAU - Kimura, Ryuichiro
AU  - Kimura R
AD  - Department of Microbiology and Oncology, Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, Okinawa 903-0215, Japan ; Transdisciplinary Research 
      Organization for Subtropics and Island Studies, University of the Ryukyus, 
      Nishihara, Okinawa 903-0213, Japan.
FAU - Mori, Naoki
AU  - Mori N
AD  - Department of Microbiology and Oncology, Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, Okinawa 903-0215, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140203
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3961453
OTO - NOTNLM
OT  - HMGB1
OT  - Tax
OT  - adult T-cell leukemia
OT  - human T-cell lymphotropic virus type I
EDAT- 2014/06/20 06:00
MHDA- 2014/06/20 06:01
PMCR- 2014/02/03
CRDT- 2014/06/20 06:00
PHST- 2013/07/14 00:00 [received]
PHST- 2014/01/15 00:00 [accepted]
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2014/06/20 06:01 [medline]
PHST- 2014/02/03 00:00 [pmc-release]
AID - ol-07-04-1239 [pii]
AID - 10.3892/ol.2014.1851 [doi]
PST - ppublish
SO  - Oncol Lett. 2014 Apr;7(4):1239-1242. doi: 10.3892/ol.2014.1851. Epub 2014 Feb 3.