PMID- 24944885 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140619 LR - 20211021 IS - 2211-7539 (Print) IS - 2211-7539 (Electronic) IS - 2211-7539 (Linking) VI - 5 DP - 2014 Jul TI - Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation. PG - 16-9 LID - 10.1016/j.mmcr.2014.05.001 [doi] AB - Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS). FAU - Kiggundu, Reuben AU - Kiggundu R AD - Infectious Disease Institute, Makerere University, Kampala, Uganda. FAU - Rhein, Joshua AU - Rhein J AD - Infectious Disease Institute, Makerere University, Kampala, Uganda ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA. FAU - Meya, David B AU - Meya DB AD - Infectious Disease Institute, Makerere University, Kampala, Uganda ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA. FAU - Boulware, David R AU - Boulware DR AD - Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA. FAU - Bahr, Nathan C AU - Bahr NC AD - Infectious Disease Institute, Makerere University, Kampala, Uganda ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA. LA - eng GR - R01 AI078934/AI/NIAID NIH HHS/United States GR - R01 NS086312/NS/NINDS NIH HHS/United States GR - R25 TW009345/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20140529 PL - Netherlands TA - Med Mycol Case Rep JT - Medical mycology case reports JID - 101598259 PMC - PMC4060260 OTO - NOTNLM OT - AIDS OT - Cryptococcus meningitis OT - HIV OT - Immune reconstitution inflammatory syndrome OT - Postpartum OT - Pregnancy EDAT- 2014/06/20 06:00 MHDA- 2014/06/20 06:01 PMCR- 2014/05/29 CRDT- 2014/06/20 06:00 PHST- 2014/04/06 00:00 [received] PHST- 2014/04/30 00:00 [revised] PHST- 2014/05/16 00:00 [accepted] PHST- 2014/06/20 06:00 [entrez] PHST- 2014/06/20 06:00 [pubmed] PHST- 2014/06/20 06:01 [medline] PHST- 2014/05/29 00:00 [pmc-release] AID - S2211-7539(14)00014-1 [pii] AID - 10.1016/j.mmcr.2014.05.001 [doi] PST - epublish SO - Med Mycol Case Rep. 2014 May 29;5:16-9. doi: 10.1016/j.mmcr.2014.05.001. eCollection 2014 Jul.