PMID- 24944897
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20240109
IS  - 2212-8778 (Print)
IS  - 2212-8778 (Electronic)
IS  - 2212-8778 (Linking)
VI  - 3
IP  - 4
DP  - 2014 Jul
TI  - Circadian control of glucose metabolism.
PG  - 372-83
LID - 10.1016/j.molmet.2014.03.002 [doi]
AB  - The incidence of obesity and type 2 diabetes mellitus (T2DM) has risen to 
      epidemic proportions. The pathophysiology of T2DM is complex and involves insulin 
      resistance, pancreatic beta-cell dysfunction and visceral adiposity. It has been 
      known for decades that a disruption of biological rhythms (which happens the most 
      profoundly with shift work) increases the risk of developing obesity and T2DM. 
      Recent evidence from basal studies has further sparked interest in the 
      involvement of daily rhythms (and their disruption) in the development of obesity 
      and T2DM. Most living organisms have molecular clocks in almost every tissue, 
      which govern rhythmicity in many domains of physiology, such as rest/activity 
      rhythms, feeding/fasting rhythms, and hormonal secretion. Here we present the 
      latest research describing the specific role played by the molecular clock 
      mechanism in the control of glucose metabolism and speculate on how disruption of 
      these tissue clocks may lead to the disturbances in glucose homeostasis.
FAU - Kalsbeek, Andries
AU  - Kalsbeek A
AD  - Department of Endocrinology and Metabolism, Academic Medical Center (AMC), 
      University of Amsterdam, The Netherlands ; Hypothalamic Integration Mechanisms, 
      Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
FAU - la Fleur, Susanne
AU  - la Fleur S
AD  - Department of Endocrinology and Metabolism, Academic Medical Center (AMC), 
      University of Amsterdam, The Netherlands.
FAU - Fliers, Eric
AU  - Fliers E
AD  - Department of Endocrinology and Metabolism, Academic Medical Center (AMC), 
      University of Amsterdam, The Netherlands.
LA  - eng
GR  - R01 DK078750/DK/NIDDK NIH HHS/United States
GR  - R01 HL113180/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140319
PL  - Germany
TA  - Mol Metab
JT  - Molecular metabolism
JID - 101605730
PMC - PMC4060304
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Circadian rhythm
OT  - Diabetes
OT  - Glucose
OT  - Hypothalamus
EDAT- 2014/06/20 06:00
MHDA- 2014/06/20 06:01
PMCR- 2014/03/19
CRDT- 2014/06/20 06:00
PHST- 2014/02/13 00:00 [received]
PHST- 2014/03/05 00:00 [revised]
PHST- 2014/03/07 00:00 [accepted]
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2014/06/20 06:01 [medline]
PHST- 2014/03/19 00:00 [pmc-release]
AID - S2212-8778(14)00068-4 [pii]
AID - 10.1016/j.molmet.2014.03.002 [doi]
PST - epublish
SO  - Mol Metab. 2014 Mar 19;3(4):372-83. doi: 10.1016/j.molmet.2014.03.002. 
      eCollection 2014 Jul.