PMID- 24945188
OWN - NLM
STAT- MEDLINE
DCOM- 20150309
LR  - 20211021
IS  - 2291-2797 (Electronic)
IS  - 2291-2789 (Print)
IS  - 2291-2789 (Linking)
VI  - 28
IP  - 6
DP  - 2014 Jun
TI  - Association between proton pump inhibitor use and spontaneous bacterial 
      peritonitis in cirrhotic patients with ascites.
PG  - 330-4
AB  - BACKGROUND: There are data suggesting a link between proton pump inhibitor (PPI) 
      use and the development of spontaneous bacterial peritonitis (SBP) in cirrhotic 
      patients with ascites; however, these data are controversial. OBJECTIVE: To 
      assess whether the use of PPIs in cirrhotic patients with ascites is associated 
      with an increased risk for SBP. METHODS: A retrospective case-control study (June 
      2004 to June 2010) was conducted at the Centre Hospitalier de l'Universite de 
      Montreal in Montreal, Quebec. Fifty-one cirrhotic patients admitted with 
      paracentesis-proven SBP (>/=250 neutrophils/mm3), occurring within seven days of 
      hospital admission, met the inclusion criteria. These patients were matched 1:2 
      (for age, Child-Pugh class and year of admission) with 102 comparable cirrhotic 
      patients with ascites who were admitted for conditions other than SBP. RESULTS: 
      Patients with SBP had a significantly higher rate of pre-hospital PPI use (60.8%) 
      compared with cirrhotic patients without SBP (42.2%; P=0.03). On multivariate 
      analysis, PPI use was the only factor independently associated with SBP (OR 2.09 
      [95% CI 1.04 to 4.23]; P=0.04). Thirty-five (35%) patients in both groups had no 
      documented indication for PPI use in their charts. Forty-five percent of the 
      remaining cirrhotic patients with SBP had an inappropriate indication, as defined 
      in the protocol, for PPI use compared with 25% of controls. CONCLUSIONS: 
      Cirrhotic patients with SBP were twice as likely to have taken PPIs than patients 
      without SBP. These findings reinforce the association between PPI use and SBP 
      observed in other studies. A high percentage of cirrhotic patients were taking a 
      PPI without any documented indication.
FAU - Ratelle, Melissa
AU  - Ratelle M
FAU - Perreault, Sylvie
AU  - Perreault S
FAU - Villeneuve, Jean-Pierre
AU  - Villeneuve JP
FAU - Tremblay, Lydjie
AU  - Tremblay L
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - Can J Gastroenterol Hepatol
JT  - Canadian journal of gastroenterology & hepatology
JID - 101623613
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Ascites/complications/drug therapy
MH  - Case-Control Studies
MH  - Female
MH  - Gram-Negative Bacteria/isolation & purification
MH  - Gram-Negative Bacterial Infections/epidemiology/microbiology
MH  - Gram-Positive Bacteria/isolation & purification
MH  - Gram-Positive Bacterial Infections/epidemiology/microbiology
MH  - Hospitals, University
MH  - Humans
MH  - Liver Cirrhosis/complications/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Peritonitis/*epidemiology/microbiology
MH  - Proton Pump Inhibitors/*administration & dosage/adverse effects
MH  - Quebec/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC4072237
EDAT- 2014/06/20 06:00
MHDA- 2015/03/10 06:00
PMCR- 2014/12/01
CRDT- 2014/06/20 06:00
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/03/10 06:00 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - cjgh-28-330 [pii]
AID - 10.1155/2014/751921 [doi]
PST - ppublish
SO  - Can J Gastroenterol Hepatol. 2014 Jun;28(6):330-4. doi: 10.1155/2014/751921.