PMID- 24946039
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20231213
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 44
DP  - 2014 Jul-Aug
TI  - Prenatal tobacco exposure and response inhibition in school-aged children: an 
      event-related potential study.
PG  - 81-8
LID - S0892-0362(14)00131-7 [pii]
LID - 10.1016/j.ntt.2014.06.003 [doi]
AB  - Prenatal cigarette smoke exposure (PCSE) has been linked to problems in 
      behavioral inhibition and attention deficit hyperactivity disorder in children in 
      several epidemiological studies. We used event-related potentials (ERPs) to 
      examine the effects of PCSE on neural correlates of inhibitory control of 
      behavior. In a prospective longitudinal study on child development in the 
      Canadian Arctic, we assessed 186 Inuit children (mean age=11.3years) on a visual 
      Go/No-go response inhibition paradigm. PCSE was assessed through maternal recall. 
      Potential confounders were documented from a maternal interview, and exposure to 
      neurotoxic environmental contaminants was assessed from umbilical cord and child 
      blood samples. PCSE was not related to behavioral performance on this simple 
      response inhibition task. Nevertheless, this exposure was associated with smaller 
      amplitudes of the N2 and P3 components elicited by No-go stimuli, suggesting an 
      impairment in the neural processes underlying response inhibition. Amplitude of 
      the No-go P3 component was also inversely associated with behavioral measures of 
      externalizing problems and hyperactivity/impulsivity in the classroom. This study 
      is the first to report neurophysiological evidence of impaired response 
      inhibition in school-aged children exposed to tobacco smoke in utero. Effects 
      were found on ERP components associated with conflict processing and inhibition 
      of a prepotent response, indicating neurophysiological deficits that may play a 
      critical role in the attention and behavior problems observed in children with 
      PCSE.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Boucher, Olivier
AU  - Boucher O
AD  - Centre de Recherche du Centre Hospitalier Universitaire de Quebec, Quebec, 
      Quebec, Canada; Centre de Recherche en Neuropsychologie et Cognition, Departement 
      de Psychologie, Universite de Montreal, Montreal, Quebec, Canada.
FAU - Jacobson, Joseph L
AU  - Jacobson JL
AD  - Department of Psychiatry and Behavioral Neurosciences, Wayne State University 
      School of Medicine, Detroit, MI, USA.
FAU - Burden, Matthew J
AU  - Burden MJ
AD  - Department of Psychiatry and Behavioral Neurosciences, Wayne State University 
      School of Medicine, Detroit, MI, USA.
FAU - Dewailly, Eric
AU  - Dewailly E
AD  - Centre de Recherche du Centre Hospitalier Universitaire de Quebec, Quebec, 
      Quebec, Canada; Universite Laval, Quebec, Quebec, Canada.
FAU - Jacobson, Sandra W
AU  - Jacobson SW
AD  - Department of Psychiatry and Behavioral Neurosciences, Wayne State University 
      School of Medicine, Detroit, MI, USA.
FAU - Muckle, Gina
AU  - Muckle G
AD  - Centre de Recherche du Centre Hospitalier Universitaire de Quebec, Quebec, 
      Quebec, Canada; Universite Laval, Quebec, Quebec, Canada. Electronic address: 
      gina.muckle@psy.ulaval.ca.
LA  - eng
GR  - CAPMC/CIHR/Canada
GR  - R01 ES007902/ES/NIEHS NIH HHS/United States
GR  - R01-ES007902/ES/NIEHS NIH HHS/United States
GR  - F32 AA014730/AA/NIAAA NIH HHS/United States
GR  - F32-AA14730/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140616
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Smoke)
SB  - IM
MH  - Brain/*drug effects/*physiopathology
MH  - Child
MH  - Evoked Potentials, Visual
MH  - Female
MH  - Humans
MH  - *Inhibition, Psychological
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology/*psychology
MH  - Smoke/*adverse effects
MH  - Nicotiana/*adverse effects
PMC - PMC4112075
MID - NIHMS606754
OTO - NOTNLM
OT  - Cigarette
OT  - Event-related potentials
OT  - Go/No-go
OT  - Inhibition
OT  - Nicotine
OT  - Pregnancy
COIS- Conflict of interest statement: The authors declare that there are no conflicts 
      of interest.
EDAT- 2014/06/20 06:00
MHDA- 2015/03/07 06:00
PMCR- 2015/07/01
CRDT- 2014/06/20 06:00
PHST- 2014/03/14 00:00 [received]
PHST- 2014/06/04 00:00 [revised]
PHST- 2014/06/05 00:00 [accepted]
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - S0892-0362(14)00131-7 [pii]
AID - 10.1016/j.ntt.2014.06.003 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2014 Jul-Aug;44:81-8. doi: 10.1016/j.ntt.2014.06.003. Epub 
      2014 Jun 16.