PMID- 24946073
OWN - NLM
STAT- MEDLINE
DCOM- 20150814
LR  - 20140721
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 271
DP  - 2014 Sep 1
TI  - APOE and BDNF Val66Met polymorphisms combine to influence episodic memory 
      function in older adults.
PG  - 309-15
LID - S0166-4328(14)00396-9 [pii]
LID - 10.1016/j.bbr.2014.06.022 [doi]
AB  - Genetic polymorphisms of apolipoprotein E (APOE) and brain-derived neurotrophic 
      factor (BDNF) have shown inconsistent associations with healthy adult cognitive 
      functions. Recent investigations have suggested that APOE polymorphisms do not 
      contribute to non-pathological cognitive function and that any effect is likely 
      due to prodromal Alzheimer's disease (AD). Similarly, although BDNF Val66Met 
      polymorphisms affect hippocampal morphology and function, associations with 
      learning and/or memory have not always been found. This study sought to determine 
      whether APOE and BDNF polymorphisms were associated, either independently or in 
      combination, with adult cognition. Comprehensive neuropsychological assessments 
      were conducted on 433 older adults, aged 50-79 years (M=62.16, SD=6.81), which 
      yielded measures of episodic memory, working memory, executive function, and 
      language processing. Participants underwent comprehensive neuropsychological 
      assessment to ensure that only cognitively intact individuals comprised the 
      sample. APOE and BDNF polymorphic data were used as predictors in general linear 
      models that assessed composite cognitive domain variables, while covarying for 
      education and age. Although no main effects for APOE or BDNF were found, the 
      analysis identified a significant APOExBDNF interaction that predicted episodic 
      memory performance (p=.02, eta(2)=.02). Post-hoc analyses demonstrated that in BDNF 
      Val homozygotes, the cognitive consequences of APOE polymorphisms were minimal. 
      However, in BDNF Met carriers, the hypothesized beneficial/detrimental effects of 
      APOE polymorphisms were found. Our data show that concurrent consideration of 
      both APOE and BDNF polymorphisms are required in order to witness a cognitive 
      effect in healthy older adults.
CI  - Crown Copyright (c) 2014. Published by Elsevier B.V. All rights reserved.
FAU - Ward, David D
AU  - Ward DD
AD  - School of Medicine, University of Tasmania, Australia; Wicking Dementia Research 
      & Education Centre, University of Tasmania, Australia.
FAU - Summers, Mathew J
AU  - Summers MJ
AD  - School of Medicine, University of Tasmania, Australia; Wicking Dementia Research 
      & Education Centre, University of Tasmania, Australia. Electronic address: 
      Mathew.Summers@utas.edu.au.
FAU - Saunders, Nichole L
AU  - Saunders NL
AD  - Wicking Dementia Research & Education Centre, University of Tasmania, Australia.
FAU - Janssen, Pierce
AU  - Janssen P
AD  - Wicking Dementia Research & Education Centre, University of Tasmania, Australia.
FAU - Stuart, Kimberley E
AU  - Stuart KE
AD  - School of Medicine, University of Tasmania, Australia; Wicking Dementia Research 
      & Education Centre, University of Tasmania, Australia.
FAU - Vickers, James C
AU  - Vickers JC
AD  - School of Medicine, University of Tasmania, Australia; Wicking Dementia Research 
      & Education Centre, University of Tasmania, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140616
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aging/*genetics/*psychology
MH  - Apolipoproteins E/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Cognition
MH  - Female
MH  - Humans
MH  - Male
MH  - *Memory, Episodic
MH  - Memory, Short-Term
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic
MH  - Risk Factors
OTO - NOTNLM
OT  - APOE
OT  - Aging
OT  - BDNF
OT  - Episodic memory
OT  - Older adult
OT  - Polymorphism
EDAT- 2014/06/20 06:00
MHDA- 2015/08/15 06:00
CRDT- 2014/06/20 06:00
PHST- 2014/04/13 00:00 [received]
PHST- 2014/06/09 00:00 [revised]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/06/20 06:00 [entrez]
PHST- 2014/06/20 06:00 [pubmed]
PHST- 2015/08/15 06:00 [medline]
AID - S0166-4328(14)00396-9 [pii]
AID - 10.1016/j.bbr.2014.06.022 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Sep 1;271:309-15. doi: 10.1016/j.bbr.2014.06.022. Epub 2014 
      Jun 16.