PMID- 24947203
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20150225
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 144
IP  - 6
DP  - 2015 Mar 15
TI  - N-terminal Pro-B type natriuretic peptide as long-term predictor of death after 
      an acute pulmonary embolism.
PG  - 241-6
LID - S0025-7753(14)00284-X [pii]
LID - 10.1016/j.medcli.2013.11.041 [doi]
AB  - BACKGROUND AND OBJECTIVE: After an acute pulmonary embolism few long-term 
      prognostic factors have shown to be of practical use. We hypothesized that, as in 
      heart failure, natriuretic peptides could serve as biomarkers of a late 
      deleterious prognosis. PATIENTS AND METHODS: Consecutive patients admitted to an 
      Internal Medicine ward diagnosed with acute pulmonary embolism were traced 
      through the computerized system of clinical episodes of Navarra Health System and 
      by telephone calls. On hospitalization, standard evaluation was made, previous 
      history of cancer and cardiac disease was recorded, and N-terminal ProB-type 
      natriuretic peptide (NT-ProBNP), D-dimer and Troponin I were measured. In the 
      analysis all-causes death was considered. RESULTS: Two hundred and thirty-four 
      patients were traced, median age 75 [interquartile range (IQR) 16] years old, 
      women 51%. At a median time of 9.5 (IQR 29) months 52 (22%) patients had died, 38 
      (73%) dead patients had NT-ProBNP higher than 850 ng/L. NT-ProBNP in dead 
      patients was 2.741 (IQR 7.420)ng/L and 662 (IQR 2.517)ng/L in survivors 
      (p<0.001). Age (OR 4.37 CI 95% 1.04-1.16) and NT-ProBNP (OR 1.49 CI 95% 1-1.002) 
      showed to be independent factors of mortality. Between the 3rd and 20th month 
      after the diagnosis, a level of NT-ProBNP higher than 850 ng/L (sensitivity 0.86, 
      specificity 0.45 and negative predictive value 0.92) was associated with a lower 
      survival (p=0.019), hazard ratio 1.89, OR 7.67 (CI 95% 1.52-39.44) for this 
      period. CONCLUSION: Besides the unchangeable age, plasma level of NT-ProBNP 
      measured on acute pulmonary embolism could predict longer-term all-cause death.
CI  - Copyright (c) 2013 Elsevier Espana, S.L.U. All rights reserved.
FAU - Alonso-Martinez, Jose Luis
AU  - Alonso-Martinez JL
AD  - Department A of Internal Medicine, Hospital Complex of Navarra, Irunlarrea 6, 
      31008 Pamplona, Spain. Electronic address: jalonsom@cfnavarra.es.
FAU - Anniccherico-Sanchez, Francisco Javier
AU  - Anniccherico-Sanchez FJ
AD  - Department A of Internal Medicine, Hospital Complex of Navarra, Irunlarrea 6, 
      31008 Pamplona, Spain.
FAU - Urbieta-Echezarreta, Miren Aranzazu
AU  - Urbieta-Echezarreta MA
AD  - Department A of Internal Medicine, Hospital Complex of Navarra, Irunlarrea 6, 
      31008 Pamplona, Spain.
FAU - Perez-Ricarte, Sara
AU  - Perez-Ricarte S
AD  - Department A of Internal Medicine, Hospital Complex of Navarra, Irunlarrea 6, 
      31008 Pamplona, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20140616
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Pulmonary Embolism/blood/diagnosis/*mortality
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Biomarcadores
OT  - Biomarkers
OT  - N-terminal ProB-type natriuretic peptide
OT  - Prohormona N-terminal del peptido natriuretico cerebral
OT  - Pulmonary embolism
OT  - Riesgo de mortalidad
OT  - Risk of death
OT  - Tromboembolismo pulmonar
EDAT- 2014/06/21 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/06/21 06:00
PHST- 2013/08/12 00:00 [received]
PHST- 2013/11/02 00:00 [revised]
PHST- 2013/11/07 00:00 [accepted]
PHST- 2014/06/21 06:00 [entrez]
PHST- 2014/06/21 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0025-7753(14)00284-X [pii]
AID - 10.1016/j.medcli.2013.11.041 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2015 Mar 15;144(6):241-6. doi: 10.1016/j.medcli.2013.11.041. 
      Epub 2014 Jun 16.