PMID- 24948016
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20140620
IS  - 2105-0686 (Electronic)
IS  - 2105-0678 (Linking)
VI  - 208
IP  - 1
DP  - 2014
TI  - [Neurotrophins and pain].
PG  - 21-9
LID - 10.1051/jbio/2014002 [doi]
AB  - Neurotrophins are a family of trophic factors well known for their effects on 
      neuronal survival, growth and neuronal differentiation. During the last decade, a 
      large literature has shown in humans and in animal models that nerve growth 
      factor (NGF) is a peripheral mediator of pain, especially in the states of 
      inflammatory pain. NGF synthesis is indeed increased in a wide variety of 
      inflammatory diseases and NGF neutralizing molecules are effective analgesic 
      agents in these models of persistent pain. Therapeutical strategies targeting the 
      sequestering of NGF did yield very encouraging results in clinical trials (stages 
      II and III) but have been on hold since 2010 due to potential harmful effects in 
      combination with non-steroid anti-inflammatory drug. NGF regulates the expression 
      of a second neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in 
      nociceptors. BDNF is released where nociceptors are activated, and it acts as a 
      modulator of pain in the central nervous system and is involved in central 
      sensitization.
CI  - (c) Societe de Biologie, 2014.
FAU - Pezet, Sophie
AU  - Pezet S
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Neurotrophines et douleur.
DEP - 20140623
PL  - France
TA  - Biol Aujourdhui
JT  - Biologie aujourd'hui
JID - 101544020
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - Humans
MH  - Inflammation/physiopathology
MH  - Models, Neurological
MH  - Nerve Growth Factor/physiology
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Tissue Proteins/physiology
MH  - Nervous System/growth & development
MH  - Neuralgia/physiopathology
MH  - Neurogenesis
MH  - Pain/*physiopathology
MH  - Pain Perception/physiology
MH  - Receptors, Nerve Growth Factor/physiology
MH  - Sensory Receptor Cells/physiology
EDAT- 2014/06/21 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/06/21 06:00
PHST- 2013/12/20 00:00 [received]
PHST- 2014/06/21 06:00 [entrez]
PHST- 2014/06/21 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - jbio140002 [pii]
AID - 10.1051/jbio/2014002 [doi]
PST - ppublish
SO  - Biol Aujourdhui. 2014;208(1):21-9. doi: 10.1051/jbio/2014002. Epub 2014 Jun 23.