PMID- 24949816
OWN - NLM
STAT- MEDLINE
DCOM- 20141003
LR  - 20171116
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 133
DP  - 2014 Aug
TI  - Persistent organic pollutant levels in human visceral and subcutaneous adipose 
      tissue in obese individuals--depot differences and dysmetabolism implications.
PG  - 170-7
LID - S0013-9351(14)00187-X [pii]
LID - 10.1016/j.envres.2014.05.026 [doi]
AB  - BACKGROUND: The role of persistent organic pollutants (POPs) with endocrine 
      disrupting activity in the aetiology of obesity and other metabolic dysfunctions 
      has been recently highlighted. Adipose tissue (AT) is a common site of POPs 
      accumulation where they can induce adverse effects on human health. OBJECTIVES: 
      To evaluate the presence of POPs in human visceral (vAT) and subcutaneous (scAT) 
      adipose tissue in a sample of Portuguese obese patients that underwent bariatric 
      surgery, and assess their putative association with metabolic disruption 
      preoperatively, as well as with subsequent body mass index (BMI) reduction. 
      METHODS: AT samples (n=189) from obese patients (BMI >/= 35) were collected and the 
      levels of 13 POPs were determined by gas chromatography with electron-capture 
      detection (GC-ECD). Anthropometric and biochemical data were collected at the 
      time of surgery. BMI variation was evaluated after 12 months and adipocyte size 
      was measured in AT samples. RESULTS: Our data confirm that POPs are pervasive in 
      this obese population (96.3% of detection on both tissues), their abundance 
      increasing with age (RS=0.310, p<0.01) and duration of obesity (RS=0.170, 
      p<0.05). We observed a difference in AT depot POPs storage capability, with 
      higher levels of SigmaPOPs in vAT (213.9 +/- 204.2 compared to 155.1 +/- 147.4 ng/g of 
      fat, p<0.001), extremely relevant when evaluating their metabolic impact. 
      Furthermore, there was a positive correlation between POP levels and the presence 
      of metabolic syndrome components, namely dysglycaemia and hypertension, and more 
      importantly with cardiovascular risk (RS=0.277, p<0.01), with relevance for vAT 
      (RS=0.315, p<0.01). Finally, we observed an interesting relation of higher POP 
      levels with lower weight loss in older patients. CONCLUSION: Our sample of obese 
      subjects allowed us to highlight the importance of POPs stored in AT on the 
      development of metabolic dysfunction in a context of obesity, shifting the focus 
      to their metabolic effects and not only for their recognition as environmental 
      obesogens.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Pestana, Diogo
AU  - Pestana D
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal; CINTESIS-Center for 
      Research in Health Technologies and Information Systems, P-4200-450 Porto, 
      Portugal. Electronic address: diogopestana@gmail.com.
FAU - Faria, Gil
AU  - Faria G
AD  - General Surgery Department, S. Joao Hospital, Faculty of Medicine, University of 
      Porto, P-4200-450 Porto, Portugal.
FAU - Sa, Carla
AU  - Sa C
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Fernandes, Virginia C
AU  - Fernandes VC
AD  - Chemistry Investigation Centre (CIQ), Department of Chemistry, Faculty of 
      Sciences, University of Porto, P-4169-007 Porto, Portugal; Requimte-Instituto 
      Superior de Engenharia, Instituto Politecnico do Porto, P-4200-072 Porto, 
      Portugal.
FAU - Teixeira, Diana
AU  - Teixeira D
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Norberto, Sonia
AU  - Norberto S
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Faria, Ana
AU  - Faria A
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal; Chemistry 
      Investigation Centre (CIQ), Department of Chemistry, Faculty of Sciences, 
      University of Porto, P-4169-007 Porto, Portugal; Faculty of Nutrition and Food 
      Sciences, University of Porto, P-4200-465 Porto, Portugal.
FAU - Meireles, Manuela
AU  - Meireles M
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Marques, Claudia
AU  - Marques C
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Correia-Sa, Luisa
AU  - Correia-Sa L
AD  - Chemistry Investigation Centre (CIQ), Department of Chemistry, Faculty of 
      Sciences, University of Porto, P-4169-007 Porto, Portugal.
FAU - Cunha, Ana
AU  - Cunha A
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Guimaraes, Joao T
AU  - Guimaraes JT
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal; Department of Clinical 
      Pathology, Hospital S. Joao, P-4200-450 Porto, Portugal.
FAU - Taveira-Gomes, Antonio
AU  - Taveira-Gomes A
AD  - General Surgery Department, S. Joao Hospital, Faculty of Medicine, University of 
      Porto, P-4200-450 Porto, Portugal.
FAU - Santos, Ana Cristina
AU  - Santos AC
AD  - Department of Hygiene and Epidemiology, Faculty of Medicine and Institute of 
      Public Health, University of Porto, P-4200-450 Porto, Portugal.
FAU - Domingues, Valentina F
AU  - Domingues VF
AD  - Requimte-Instituto Superior de Engenharia, Instituto Politecnico do Porto, 
      P-4200-072 Porto, Portugal.
FAU - Delerue-Matos, Cristina
AU  - Delerue-Matos C
AD  - Requimte-Instituto Superior de Engenharia, Instituto Politecnico do Porto, 
      P-4200-072 Porto, Portugal.
FAU - Monteiro, Rosario
AU  - Monteiro R
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal.
FAU - Calhau, Conceicao
AU  - Calhau C
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, P-4200-450 Porto, Portugal; CINTESIS-Center for 
      Research in Health Technologies and Information Systems, P-4200-450 Porto, 
      Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140618
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Comorbidity
MH  - Endocrine Disruptors/adverse effects/analysis/*metabolism
MH  - Environmental Pollutants/adverse effects/analysis/*metabolism
MH  - Female
MH  - Humans
MH  - Intra-Abdominal Fat/chemistry/*metabolism
MH  - Male
MH  - Metabolic Syndrome/chemically induced/epidemiology/*metabolism
MH  - Middle Aged
MH  - Obesity/chemically induced/epidemiology/*metabolism
MH  - Portugal/epidemiology
MH  - Subcutaneous Fat, Abdominal/chemistry/*metabolism
MH  - Weight Loss
MH  - Young Adult
OTO - NOTNLM
OT  - Adipose tissue
OT  - Bariatric surgery
OT  - Metabolic syndrome
OT  - Obesity
OT  - Persistent organic pollutants
EDAT- 2014/06/21 06:00
MHDA- 2014/10/04 06:00
CRDT- 2014/06/21 06:00
PHST- 2013/10/18 00:00 [received]
PHST- 2014/04/22 00:00 [revised]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/06/21 06:00 [entrez]
PHST- 2014/06/21 06:00 [pubmed]
PHST- 2014/10/04 06:00 [medline]
AID - S0013-9351(14)00187-X [pii]
AID - 10.1016/j.envres.2014.05.026 [doi]
PST - ppublish
SO  - Environ Res. 2014 Aug;133:170-7. doi: 10.1016/j.envres.2014.05.026. Epub 2014 Jun 
      18.