PMID- 24950732
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20220330
IS  - 1548-3576 (Electronic)
IS  - 1548-3568 (Linking)
VI  - 11
IP  - 3
DP  - 2014 Sep
TI  - Immune reconstitution disorders in patients with HIV infection: from pathogenesis 
      to prevention and treatment.
PG  - 223-32
LID - 10.1007/s11904-014-0213-0 [doi]
AB  - An immune reconstitution disorder occurs in up to 40 % of severely 
      immunodeficient HIV patients who commence antiretroviral therapy (ART), with an 
      immune reconstitution inflammatory syndrome (IRIS) being encountered most 
      commonly. Differences in the immunopathogenesis of an IRIS associated with 
      different types of pathogen have become apparent but common features have also 
      been defined. These include severe immunodeficiency prior to commencing ART 
      associated with a high pathogen load and 'compensatory' immune responses, 
      particularly innate immune responses, which inadequately control the pathogen and 
      increase the risk of immunopathology as the immune system recovers on ART. 
      Prevention of an IRIS may be achieved by optimising therapy for opportunistic 
      infections before ART is commenced, delaying ART or using immunomodulatory 
      therapy to prevent or suppress the immune response that causes the 
      immunopathology. However, further clinical studies are required to examine these 
      options in a systematic manner for the various types of IRIS.
FAU - Chang, C C
AU  - Chang CC
AD  - Department of Infectious Diseases, Alfred Hospital and Monash University, 
      Melbourne, 3000, Australia.
FAU - Sheikh, V
AU  - Sheikh V
FAU - Sereti, I
AU  - Sereti I
FAU - French, M A
AU  - French MA
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Curr HIV/AIDS Rep
JT  - Current HIV/AIDS reports
JID - 101235661
SB  - IM
MH  - Autoimmune Diseases
MH  - Cryptococcosis/complications
MH  - HIV Infections/*complications/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/etiology/*prevention & 
      control/*therapy
MH  - Tuberculosis/complications
EDAT- 2014/06/22 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/06/22 06:00
PHST- 2014/06/22 06:00 [entrez]
PHST- 2014/06/22 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - 10.1007/s11904-014-0213-0 [doi]
PST - ppublish
SO  - Curr HIV/AIDS Rep. 2014 Sep;11(3):223-32. doi: 10.1007/s11904-014-0213-0.