PMID- 24951171
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20221207
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 36
IP  - 4
DP  - 2015 Apr
TI  - Association of maternal KIR and fetal HLA-C genes with the risk of preeclampsia 
      in the Chinese Han population.
PG  - 433-7
LID - S0143-4004(14)00221-5 [pii]
LID - 10.1016/j.placenta.2014.05.008 [doi]
AB  - INTRODUCTION: This study is to investigate the distribution of inhibitory and 
      activating killer-cell immunoglobulin-like receptors (KIRs) and the combination 
      of KIR/human leukocyte antigen (HLA)-C in women with preeclampsia in the Chinese 
      Han population. METHODS: A total of 271 patients and 295 controls were enrolled 
      in our study. The inhibitory/activating KIR and HLA-C genes were detected using 
      the PCR-SSP (polymerase chain reaction with sequence-specific primers) method. 
      RESULTS: Our result showed that decreased numbers of individual activating KIR 
      genes (2DS2, 2DS3, and 2DS5) were observed in women with preeclampsia. 
      Furthermore, the gene frequency of total activating KIRs was significantly lower 
      in patients compared with that of the controls (P = 0.03). The frequency of the 
      KIR2DL1 gene was increased in women with preeclampsia when a homozygous HLA-C2 
      allele appeared in the fetus. CONCLUSION: The results suggest that a KIR genetic 
      variation might influence the risk of preeclampsia. The lack of activating KIRs 
      could possibly lower uterine natural killer (uNK) cell activation, thereby 
      contributing to the pathogenesis of preeclampsia. Moreover, the imbalance of the 
      inhibitory or activating signals at the maternal-fetal interface seems to play a 
      regulatory role in the occurrence of preeclampsia.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Long, W
AU  - Long W
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China.
FAU - Shi, Z
AU  - Shi Z
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China.
FAU - Fan, S
AU  - Fan S
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China.
FAU - Liu, L
AU  - Liu L
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China.
FAU - Lu, Y
AU  - Lu Y
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China.
FAU - Guo, X
AU  - Guo X
AD  - Maternal and Child Health Medical Institute, Nanjing Medical University 
      Affiliated Nanjing Maternal and Child Health Hospital, Nanjing 210004, China.
FAU - Rong, C
AU  - Rong C
AD  - Maternal and Child Health Medical Institute, Nanjing Medical University 
      Affiliated Nanjing Maternal and Child Health Hospital, Nanjing 210004, China.
FAU - Cui, X
AU  - Cui X
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China. Electronic address: 
      cuixianwei198615@126.com.
FAU - Ding, H
AU  - Ding H
AD  - Department of Obstetrics, Nanjing Medical University Affiliated Nanjing Maternal 
      and Child Health Hospital, Nanjing 210004, China. Electronic address: 
      Longw_njfy@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL1 protein, human)
RN  - 0 (KIR2DS2 protein, human)
RN  - 0 (KIR2DS3 protein, human)
RN  - 0 (KIR2DS5 protein, human)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL1)
SB  - IM
CIN - Placenta. 2015 Aug;36(8):967. PMID: 26145227
MH  - Adult
MH  - Alleles
MH  - Asian People
MH  - China
MH  - Cohort Studies
MH  - Female
MH  - Fetal Blood
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-C Antigens/blood/*genetics/metabolism
MH  - *Histocompatibility, Maternal-Fetal
MH  - Homozygote
MH  - Humans
MH  - Pre-Eclampsia/blood/*genetics/metabolism
MH  - Pregnancy
MH  - Receptors, KIR/blood/genetics/metabolism
MH  - Receptors, KIR2DL1/blood/*genetics/metabolism
OTO - NOTNLM
OT  - HLA-C
OT  - KIR
OT  - PCR-SSP
OT  - Preeclampsia
EDAT- 2014/06/22 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/06/22 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/05/24 00:00 [accepted]
PHST- 2014/06/22 06:00 [entrez]
PHST- 2014/06/22 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0143-4004(14)00221-5 [pii]
AID - 10.1016/j.placenta.2014.05.008 [doi]
PST - ppublish
SO  - Placenta. 2015 Apr;36(4):433-7. doi: 10.1016/j.placenta.2014.05.008. Epub 2014 
      Jun 4.