PMID- 24951401
OWN - NLM
STAT- MEDLINE
DCOM- 20150226
LR  - 20211021
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 157
IP  - 1-3
DP  - 2014 Aug
TI  - Neural responses during social reflection in relatives of schizophrenia patients: 
      relationship to subclinical delusions.
PG  - 292-8
LID - S0920-9964(14)00285-0 [pii]
LID - 10.1016/j.schres.2014.05.033 [doi]
AB  - BACKGROUND: Deficits in the capacity to reflect about the self and others 
      ("social reflection" [SR]) have been identified in schizophrenia, as well as in 
      people with a genetic or clinical risk for the disorder. However, the neural 
      underpinnings of these abnormalities are incompletely understood. METHODS: 
      Responses of a network of brain regions known to be involved in self and other 
      processing (e.g., medial prefrontal cortex (MPFC), posterior cingulate cortex 
      (PCC), and superior temporal gyrus (STG)) were measured during SR in 16 
      first-degree, non-psychotic relatives (RELS) of schizophrenia patients and 16 
      healthy controls (CONS). Because of prior evidence linking dysfunction in this 
      network and delusions, associations between SR-related responses of this network 
      and subclinical delusions (measured using the Peters et al. Delusions Inventory) 
      were also examined. RESULTS: Compared with CONS, RELS showed significantly less 
      SR-related activity of the right and left PCC and STG. Moreover, response 
      magnitudes were negatively correlated with levels of delusional thinking across 
      both groups. CONCLUSIONS: These findings suggest that aberrant function of the 
      neural circuitry underpinning SR is associated with the genetic liability to 
      schizophrenia and confers vulnerability to delusional beliefs.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Brent, Benjamin K
AU  - Brent BK
AD  - The Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard 
      Medical School, Boston, MA, United States; The Department of Psychiatry, 
      Massachusetts General Hospital, Harvard Medical School, Boston, MA, United 
      States. Electronic address: bbrent@bidmc.harvard.edu.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - The Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard 
      Medical School, Boston, MA, United States; The Department of Psychiatry, 
      Massachusetts General Hospital, Harvard Medical School, Boston, MA, United 
      States.
FAU - Coombs, Garth 3rd
AU  - Coombs G 3rd
AD  - The Department of Psychology, Harvard University, Cambridge, MA, United States.
FAU - Keshavan, Matcheri S
AU  - Keshavan MS
AD  - The Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard 
      Medical School, Boston, MA, United States.
FAU - Moran, Joseph M
AU  - Moran JM
AD  - The Center for Brain Sciences, Harvard University, Cambridge, MA, United States; 
      U.S. Army Natick Soldier Research, Development, and Engineering Center, United 
      States.
FAU - Holt, Daphne J
AU  - Holt DJ
AD  - The HST-MIT Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, 
      United States; The Department of Psychiatry, Massachusetts General Hospital, 
      Harvard Medical School, Boston, MA, United States.
LA  - eng
GR  - KL2 TR001100/TR/NCATS NIH HHS/United States
GR  - L30 MH091727/MH/NIMH NIH HHS/United States
GR  - T32 16259/PHS HHS/United States
GR  - KL2 RR 025757/RR/NCRR NIH HHS/United States
GR  - K23 MH076054/MH/NIMH NIH HHS/United States
GR  - KL2 RR025757/RR/NCRR NIH HHS/United States
GR  - K23MH076054/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140617
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Delusions/*physiopathology
MH  - *Family
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Neuropsychological Tests
MH  - Reaction Time
MH  - *Schizophrenia/genetics/physiopathology
MH  - *Social Perception
MH  - Thinking/*physiology
PMC - PMC4109724
MID - NIHMS603166
OTO - NOTNLM
OT  - Delusions
OT  - Genetic risk
OT  - Relatives
OT  - Schizophrenia
OT  - Social reflection
COIS- Conflict of Interest The authors have no conflicts of interest to declare.
EDAT- 2014/06/22 06:00
MHDA- 2015/02/27 06:00
PMCR- 2015/08/01
CRDT- 2014/06/22 06:00
PHST- 2014/03/29 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/05/23 00:00 [accepted]
PHST- 2014/06/22 06:00 [entrez]
PHST- 2014/06/22 06:00 [pubmed]
PHST- 2015/02/27 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - S0920-9964(14)00285-0 [pii]
AID - 10.1016/j.schres.2014.05.033 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Aug;157(1-3):292-8. doi: 10.1016/j.schres.2014.05.033. Epub 
      2014 Jun 17.