PMID- 24951480
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 26
IP  - 6
DP  - 2014 Jun
TI  - COP1 and phyB Physically Interact with PIL1 to Regulate Its Stability and 
      Photomorphogenic Development in Arabidopsis.
PG  - 2441-2456
AB  - In Arabidopsis thaliana, the cryptochrome and phytochrome photoreceptors act 
      together to promote photomorphogenic development. The cryptochrome and 
      phytochrome signaling mechanisms interact directly with CONSTITUTIVELY 
      PHOTOMORPHOGENIC1 (COP1), a RING motif-containing E3 ligase that acts to 
      negatively regulate photomorphogenesis. COP1 interacts with and ubiquitinates the 
      transcription factors that promote photomorphogenesis, such as ELONGATED 
      HYPOCOTYL5 and LONG HYPOCOTYL IN FAR-RED1 (HFR1), to inhibit photomorphogenic 
      development. Here, we show that COP1 physically interacts with PIF3-LIKE1 (PIL1) 
      and promotes PIL1 degradation via the 26S proteasome. We further demonstrate that 
      phyB physically interacts with PIL1 and enhances PIL1 protein accumulation upon 
      red light irradiation, probably through suppressing the COP1-PIL1 association. 
      Biochemical and genetic studies indicate that PIL1 and HFR1 form heterodimers and 
      promote photomorphogenesis cooperatively. Moreover, we demonstrate that PIL1 
      interacts with PIF1, 3, 4, and 5, resulting in the inhibition of the 
      transcription of PIF direct-target genes. Our results reveal that PIL1 stability 
      is regulated by phyB and COP1, likely through physical interactions, and that 
      PIL1 coordinates with HFR1 to inhibit the transcriptional activity of PIFs, 
      suggesting that PIL1, HFR1, and PIFs constitute a subset of antagonistic basic 
      helix-loop-helix factors acting downstream of phyB and COP1 to regulate 
      photomorphogenic development.
CI  - (c) 2014 American Society of Plant Biologists. All rights reserved.
FAU - Luo, Qian
AU  - Luo Q
AD  - Key Laboratory of Urban Agriculture (South) Ministry of Agriculture and School of 
      Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
FAU - Lian, Hong-Li
AU  - Lian HL
AD  - School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai 
      200240, China.
FAU - He, Sheng-Bo
AU  - He SB
AD  - Key Laboratory of Urban Agriculture (South) Ministry of Agriculture and School of 
      Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
FAU - Li, Ling
AU  - Li L
AD  - School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai 
      200240, China.
FAU - Jia, Kun-Peng
AU  - Jia KP
AD  - Key Laboratory of Urban Agriculture (South) Ministry of Agriculture and School of 
      Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China.
FAU - Yang, Hong-Quan
AU  - Yang HQ
AD  - School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai 
      200240, China Collaborative Innovation Center for Genetics and Development, Fudan 
      University, Shanghai 200433, China hqyang@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20140620
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
PMC - PMC4114944
EDAT- 2014/06/22 06:00
MHDA- 2014/06/22 06:01
PMCR- 2015/06/01
CRDT- 2014/06/22 06:00
PHST- 2014/06/22 06:00 [entrez]
PHST- 2014/06/22 06:00 [pubmed]
PHST- 2014/06/22 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - tpc.113.121657 [pii]
AID - 121657 [pii]
AID - 10.1105/tpc.113.121657 [doi]
PST - ppublish
SO  - Plant Cell. 2014 Jun;26(6):2441-2456. doi: 10.1105/tpc.113.121657. Epub 2014 Jun 
      20.