PMID- 24952213
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20181202
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 75
IP  - 8
DP  - 2014 Aug
TI  - Association of STAT6 variants with asthma risk: a systematic review and 
      meta-analysis.
PG  - 847-53
LID - S0198-8859(14)00171-2 [pii]
LID - 10.1016/j.humimm.2014.06.007 [doi]
AB  - A large number of studies have reported that the genetic variants in STAT6 gene 
      may be implicated in susceptibility to asthma, but with inconsistent results. 
      Therefore, the aim of this meta-analysis was to determine the likelihood of 
      developing asthma for the individuals with different STAT6 variants. The database 
      including Pubmed, Embase and CNKI (Chinese National Knowledge Infrastructure) 
      were searched to find the relevant papers. Data were extracted by two independent 
      reviewers and the odds radios (ORs) were pooled with 95% confidence intervals 
      (CIs), using random effect or fixed effect models as appropriate, to indicate the 
      risk of asthma for different STAT6 variants. The heterogeneity and bias were 
      tested for each pooled result. Data from 19 studies were pooled that reported 
      associations of rs324015, rs71802646 and rs324011 in STAT6 gene with asthma risk. 
      The results demonstrated that 13GT and short GT in rs71802646 were both 
      associated with increased risk of asthma in overall analysis (OR = 1.26 for 13GT 
      and 1.30 for short GT). Further, subgroup analysis showed an increased risk of 
      asthma in Asian population with 13GT (OR = 1.21), 14GT (OR = 1.97) and short GT 
      (OR = 1.27). Besides, 13GT, 14GT and short GT all contributed to higher risk of 
      atopic asthma, with OR 1.50, 2.21 and 1.65 respectively. However, rs324015 (G>A) 
      appeared to be associated with decreased risk for atopic asthma (with OR = 0.83, 
      0.68 and 0.79 for A, AA and AA+AG respectively). Both overall and subgroup 
      analyses indicated no effect of rs324011 on asthma risk. In conclusion, our 
      meta-analyses suggest that short GT repeats of rs71802646 in STAT6 contribute to 
      higher risk for asthma, while rs324015 may have a protective effect on atopic 
      asthma.
CI  - Copyright (c) 2014 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Qian, Xubo
AU  - Qian X
AD  - Department of Pediatrics, Xiguan Community Health-care Center, Jinhua 321017, 
      Zhejiang Province, PR China.
FAU - Gao, Yuan
AU  - Gao Y
AD  - Department of Pediatrics, Jinhua Central Hospital, Jinhua 321000, Zhejiang 
      Province, PR China.
FAU - Ye, Xiaohong
AU  - Ye X
AD  - Department of General Practice, Xiguan Community Health-care Center, Jinhua 
      321017, Zhejiang Province, PR China.
FAU - Lu, Meiping
AU  - Lu M
AD  - Department of Rheumatology Immunology & Allergy, Children's Hospital, Zhejiang 
      University School of Medicine, Hangzhou 310003, PR China. Electronic address: 
      meipinglu@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140619
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (STAT6 protein, human)
SB  - IM
MH  - Adult
MH  - Asthma/*genetics/pathology
MH  - Case-Control Studies
MH  - Child
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - STAT6 Transcription Factor/*genetics
OTO - NOTNLM
OT  - Asthma
OT  - Genetic polymorphism
OT  - Meta-analysis
OT  - STAT6
EDAT- 2014/06/22 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/22 06:00
PHST- 2014/01/18 00:00 [received]
PHST- 2014/06/05 00:00 [revised]
PHST- 2014/06/07 00:00 [accepted]
PHST- 2014/06/22 06:00 [entrez]
PHST- 2014/06/22 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S0198-8859(14)00171-2 [pii]
AID - 10.1016/j.humimm.2014.06.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2014 Aug;75(8):847-53. doi: 10.1016/j.humimm.2014.06.007. Epub 2014 
      Jun 19.