PMID- 24953294
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20140623
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 25
IP  - 4
DP  - 2014 Jun
TI  - Immunoglobulin A and immunoglobulin G antibodies against beta-lactoglobulin and 
      gliadin at age 1 associate with immunoglobulin E sensitization at age 6.
PG  - 329-37
LID - 10.1111/pai.12246 [doi]
AB  - BACKGROUND: Serum immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies 
      against wheat gliadin and cow's milk beta-lactoglobulin (BLG) are considered markers 
      of gut permeability and inflammation which modulate the development of mucosal 
      tolerance. Living on a farm has been shown to decrease allergies in children. Our 
      aim was to study whether farm environment affected mucosal tolerance, 
      immunoglobulin E (IgE) sensitization, or allergic diseases. METHODS: The PASTURE 
      birth cohort study was conducted in Finland, France, Germany, Austria, and 
      Switzerland. At age 1, we measured serum IgA and IgG against wheat gliadin (N = 
      636) and cow's milk BLG (N = 639) using ELISA. Serum-specific IgE was measured at 
      ages 1 and 6 (N = 459). Data on environmental factors and allergic diseases were 
      collected by questionnaires. Discrete time hazard and multivariate logistic 
      regression models were used for analyses. RESULTS: Increased IgA or IgG 
      antibodies against BLG at age 1 increased the risk of sensitization to at least 
      one of the measured allergens or food allergens at age 6. Increased IgG against 
      gliadin at age 1 increased the risk of sensitization to any, at least one 
      inhalant, or at least one food allergen at age 6. Early exposure to cow's milk 
      formula associated with increased IgA or IgG against BLG. No association with 
      farming or clinical allergy was found. CONCLUSIONS: Increased IgA or IgG against 
      BLG or gliadin at age 1 was associated with IgE sensitization at age 6. We 
      suggest that an enhanced antibody response to food antigens reflects mucosal 
      tolerance aberrancies, e.g., altered microbiota and/or increased gut 
      permeability, which is later seen as sensitization to allergens.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Orivuori, Laura
AU  - Orivuori L
AD  - Department of Vaccination and Immune Protection, National Institute for Health 
      and Welfare, Helsinki, Finland.
FAU - Mustonen, Kirsi
AU  - Mustonen K
FAU - Roduit, Caroline
AU  - Roduit C
FAU - Braun-Fahrlander, Charlotte
AU  - Braun-Fahrlander C
FAU - Dalphin, Jean-Charles
AU  - Dalphin JC
FAU - Genuneit, Jon
AU  - Genuneit J
FAU - Lauener, Roger
AU  - Lauener R
FAU - Pfefferle, Petra
AU  - Pfefferle P
FAU - Riedler, Josef
AU  - Riedler J
FAU - Weber, Juliane
AU  - Weber J
FAU - von Mutius, Erika
AU  - von Mutius E
FAU - Pekkanen, Juha
AU  - Pekkanen J
FAU - Vaarala, Outi
AU  - Vaarala O
CN  - PASTURE Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lactoglobulins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-90-3 (Gliadin)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Child
MH  - Cohort Studies
MH  - Environmental Exposure
MH  - Europe
MH  - Female
MH  - Gliadin/*immunology
MH  - Humans
MH  - Immunity, Mucosal
MH  - Immunization
MH  - Immunoglobulin A/*blood
MH  - Immunoglobulin E/*immunology
MH  - Immunoglobulin G/*blood
MH  - Infant
MH  - Intestinal Mucosa/*immunology
MH  - Lactoglobulins/*immunology
MH  - Male
MH  - Milk/immunology
MH  - Milk Hypersensitivity/*diagnosis/immunology
MH  - Prognosis
MH  - Triticum/immunology
MH  - Wheat Hypersensitivity/*diagnosis/immunology
OTO - NOTNLM
OT  - allergy
OT  - asthma
OT  - atopic dermatitis
OT  - formula milk
OT  - gliadin
OT  - gut permeability
OT  - immunoglobulin
OT  - immunoglobulin E sensitization
OT  - inflammation
OT  - beta-lactoglobulin
FIR - Karvonen, Anne
IR  - Karvonen A
FIR - Roponen, Marjut
IR  - Roponen M
FIR - Hirvonen, Maija-Riitta
IR  - Hirvonen MR
FIR - Tiittanen, Pekka
IR  - Tiittanen P
FIR - Remes, Sami
IR  - Remes S
FIR - Kaulek, Vincent
IR  - Kaulek V
FIR - Dalphin, Marie-Laure
IR  - Dalphin ML
FIR - Buchele, Gisela
IR  - Buchele G
FIR - Ege, Markus
IR  - Ege M
FIR - Depner, Martin
IR  - Depner M
FIR - Schaub, Bianca
IR  - Schaub B
FIR - Renz, Harald
IR  - Renz H
FIR - Kabesch, Michael
IR  - Kabesch M
FIR - Bitter, Sondhja
IR  - Bitter S
FIR - Loss, Georg
IR  - Loss G
FIR - Frei, Remo
IR  - Frei R
FIR - Doekes, Gert
IR  - Doekes G
EDAT- 2014/06/24 06:00
MHDA- 2015/03/25 06:00
CRDT- 2014/06/24 06:00
PHST- 2014/04/22 00:00 [accepted]
PHST- 2014/06/24 06:00 [entrez]
PHST- 2014/06/24 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
AID - 10.1111/pai.12246 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2014 Jun;25(4):329-37. doi: 10.1111/pai.12246.