PMID- 24953910
OWN - NLM
STAT- MEDLINE
DCOM- 20150717
LR  - 20151119
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 24
IP  - 6
DP  - 2014 Jun
TI  - Relationship of high sensitivity C-reactive protein with cardiac biomarkers in 
      patients presenting with acute coronary syndrome.
PG  - 387-91
AB  - OBJECTIVE: To determine high sensitivity C-reactive protein (hsCRP) levels in 
      patients with acute myocardial infarction (AMI) and its correlation with 
      classical enzyme markers of myocardial damage. STUDY DESIGN: Observational study. 
      PLACE AND DURATION OF STUDY: Department of Emergency Medicine at King Khalid 
      University Hospital, King Saud University, Riyadh and Department of Physiology, 
      from August 2010 to December 2011. METHODOLOGY: Consecutive eligible patients 
      with either ST elevation myocardial infarction (STEMI) or non-ST elevation 
      myocardial infarction (NSTEMI) who were admitted to the Emergency Department of 
      King Khalid University Hospital were recruited. A total of 71 subjects were 
      finally selected for the study. The hsCRP, Troponin I (Trop I), creatine kinase 
      myocardial bound (CK-MB), aspartate aminotransferase (AST) and lactate 
      dehydrogenase (LDH) concentrations of all patients with an acute myocardial 
      infarction (AMI) were measured. RESULTS: Among all patients 34 (47.9%) patients 
      had diabetes mellitus, 21 (29.6%) were hypertensive, and 16 (22.5%) had no 
      associated illness. Patients with STEMI had significantly higher levels of CKMB 
      (p=0.0348), LDH (p=0.0471) and hsCRP (p=0.0231) compared to NSTEMI patients. 
      While the differences were non-significant for Trop I (p=0.7022), AST (p=0.9729) 
      and Lp(a) (p=0.5985). Spearman's correlations revealed that CRP correlated 
      significantly with Trop I, CK-MB and LDH. There was a significant predictive 
      relationship of hsCRP with Trop I, LDH and CK-MB while with AST it was 
      nonsignificant. CONCLUSION: High sensitivity CRP levels is a significant 
      predictor of standard markers for myocardial damage and it may be a useful 
      prognostic marker in acute coronary syndromes.
FAU - Aseri, Zohair Al
AU  - Aseri ZA
AD  - Department of Emergency Medicine, King Khalid University Hospital, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Habib, Syed Shahid
AU  - Habib SS
AD  - Department of Emergency Physiology, King Khalid University Hospital, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Alhomida, Abdullah Saleh
AU  - Alhomida AS
AD  - Department of Biochemistry, King Khalid University Hospital, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Khan, Haseeb Ahmad
AU  - Khan HA
AD  - Department of Biochemistry, King Khalid University Hospital, King Saud 
      University, Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aspartate Aminotransferases/blood
MH  - Biomarkers/*blood
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis/*metabolism
MH  - Coronary Angiography
MH  - Creatine Kinase, MB Form/blood
MH  - Female
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*diagnosis
MH  - Predictive Value of Tests
MH  - Sensitivity and Specificity
MH  - Troponin I/blood
EDAT- 2014/06/24 06:00
MHDA- 2015/07/18 06:00
CRDT- 2014/06/24 06:00
PHST- 2012/11/05 00:00 [received]
PHST- 2014/01/06 00:00 [accepted]
PHST- 2014/06/24 06:00 [entrez]
PHST- 2014/06/24 06:00 [pubmed]
PHST- 2015/07/18 06:00 [medline]
AID - 040579197 [pii]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2014 Jun;24(6):387-91.