PMID- 24954960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 0040-4039 (Print)
IS  - 0040-4039 (Linking)
VI  - 55
IP  - 22
DP  - 2014 May 1
TI  - Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler 
      Amidination process.
PG  - 3328-3331
AB  - An isocyanide-based multicomponent reaction (IMCR) utilized for the rapid 
      assembly of novel, biologically relevant 
      dihydropyrrolo[1,2-a]quinoxalines-amidines is herein presented. Starting from 
      1-(2-aminophenyl)pyrroles, aldehydes, and isonitriles, the target heterocyclic 
      scaffold is assembled in a one-pot, operationally friendly process. With three 
      points of diversity and formation of three chemical bonds in one step, this 
      strategy proves to be very general. Novel, mild methodology for the generation of 
      amidines from secondary amine anilines and isonitriles is also introduced.
FAU - Medda, Federico
AU  - Medda F
AD  - University of Arizona, College of Pharmacy, 1703 E. Mabel St., Tucson, AZ 85721, 
      USA ; BIO5 Oro Valley, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA.
FAU - Hulme, Christopher
AU  - Hulme C
AD  - University of Arizona, College of Pharmacy, 1703 E. Mabel St., Tucson, AZ 85721, 
      USA ; BIO5 Oro Valley, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA ; 
      University of Arizona, Department of Chemistry and Biochemistry, Tucson, AZ 
      85721, USA.
LA  - eng
GR  - P41 GM086190/GM/NIGMS NIH HHS/United States
GR  - RC2 MH090878/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Tetrahedron Lett
JT  - Tetrahedron letters
JID - 2984819R
PMC - PMC4062309
MID - NIHMS588849
OTO - NOTNLM
OT  - Amidine
OT  - Isonitrile
OT  - Multicomponent reaction
OT  - Pictet-Spengler
EDAT- 2014/06/24 06:00
MHDA- 2014/06/24 06:01
PMCR- 2015/05/01
CRDT- 2014/06/24 06:00
PHST- 2014/06/24 06:00 [entrez]
PHST- 2014/06/24 06:00 [pubmed]
PHST- 2014/06/24 06:01 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 10.1016/j.tetlet.2014.04.043 [doi]
PST - ppublish
SO  - Tetrahedron Lett. 2014 May 1;55(22):3328-3331. doi: 10.1016/j.tetlet.2014.04.043.