PMID- 24955183
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140623
LR  - 20211021
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 7
IP  - 4
DP  - 2014
TI  - Impact of initial platelet count on baseline angiographic finding and end-points 
      in ST-elevation myocardial infarction referred for primary percutaneous coronary 
      intervention.
PG  - 1064-70
AB  - The baseline platelet count (BPC) in patients with acute ST elevation myocardial 
      infarction (STEMI) may reflect the baseline anjiografic finding and may also 
      predic long-term outcomes after primary percutaneous coronary intervention 
      (PPCI). Available data for the value of BPC in patients with STEMI treated with 
      PPCI are still questionable. Therefore, we sought to determine the prognostic 
      value of BPC for baseline angiographic finding and the impact of BPC on clinical 
      outcomes of patients treating with PPCI. Blood sample for BPC was obtained on 
      admission in 140 consecutive patients undergoing PPCI. Patients were divided 2 
      groups that group-1 (104 patients): TIMI flow-grade 0 and group-2 (36 patients): 
      TIMI flow-grade 1-3. Follow-up was performed at 1-9 months. Baseline demographics 
      were comparable, but, BPC was significantly higher in group-1 comparing 2 
      (293.7+/-59.8x10(9)/L vs. 237.7+/-50.9x10(9)/L, p<0.0001), pre-procedural lesion 
      length longer in group-1 comparing 2 (13.6+/-3.6 mm vs. 11.4+/-3.9 mm, p:0.003). 
      Distal embolization (19.0% vs. 0.0%, p:0.001), slow-flow (15.2% vs. 2.9%, 
      p:0.033) were more common in group-1 and mean maximum troponin-I level (9.1+/-4.2 
      mug/L vs. 5.1+/-3.9 mug/L, p<0.0001) and mean maximum creatinin kinase (2077.6+/-1378.4 
      U/L vs. 1163.4+/-869.7 U/L, p:<0.0001) were higher in group-1. In-hospital and 
      30-days major cardiac adverse events (MACEs) (16.5% vs. 5.7%), p:0.14) were 
      similarly in both groups, but, at 6-months target vessel revascularization (13.9% 
      vs. 0.0%, p:0.017) and MACEs significantly higher in the group-1 (24.1% vs. 2.9%, 
      p:0.013). CONCLUSION: A higher BPC without any antithrombotic agent is a strongly 
      predictor of total occlusion of IRA in STEMI treated with PPCI. And a higher BPC 
      associated with poor clinical outcomes at 9-months. Apart from prognostic value, 
      measuring of a BPC on admission may also provide further practical and 
      therapeutic profits.
FAU - Kaplan, Sahin
AU  - Kaplan S
AD  - Department of Cardiology, KTU, Faculty of Medicine Trabzon, Turkey.
FAU - Kaplan, Safiye Tuba
AU  - Kaplan ST
AD  - Department of Internal Medicine, Numune State Hospital Trabzon, Turkey.
FAU - Kiris, Abdulkadir
AU  - Kiris A
AD  - Department of Cardiology, KTU, Faculty of Medicine Trabzon, Turkey.
FAU - Gedikli, Omer
AU  - Gedikli O
AD  - Department of Cardiology, KTU, Faculty of Medicine Trabzon, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140415
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4057862
OTO - NOTNLM
OT  - Baseline platelet count
OT  - ST-elevation myocardial infarction
OT  - angiographic findings
OT  - clinical outcome
OT  - infarct related artery patency
OT  - percutaneous coronary intervention
OT  - primary PCI
EDAT- 2014/06/24 06:00
MHDA- 2014/06/24 06:01
PMCR- 2014/04/15
CRDT- 2014/06/24 06:00
PHST- 2014/02/13 00:00 [received]
PHST- 2014/04/12 00:00 [accepted]
PHST- 2014/06/24 06:00 [entrez]
PHST- 2014/06/24 06:00 [pubmed]
PHST- 2014/06/24 06:01 [medline]
PHST- 2014/04/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2014 Apr 15;7(4):1064-70. eCollection 2014.