PMID- 24955870
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 37
DP  - 2014 Oct
TI  - Levels of brain derived neurotrophic factors across gestation in women with 
      preeclampsia.
PG  - 36-40
LID - S0736-5748(14)00090-2 [pii]
LID - 10.1016/j.ijdevneu.2014.06.008 [doi]
AB  - Preeclampsia (PE) is a major pregnancy complication of placental origin which 
      leads to adverse pregnancy outcome. Brain derived neurotrophic factor (BDNF) is 
      suggested to promote trophoblast growth and regulate placental and fetal 
      development. This study for the first time examines the levels of maternal plasma 
      BDNF at various time points during gestation, cord plasma and placental BDNF 
      levels and their association with birth outcome in women with PE. Normotensive 
      control (NC) women (n=89) and women with PE (n=61) were followed at three 
      different time points [16-20 weeks (T1), 26-30 weeks (T2) and at delivery (T3)]. 
      Maternal blood at all time points and cord blood was collected. Results indicate 
      that maternal BDNF levels at T1 (p=0.050) and T3 (p=0.025) were lower in women 
      with PE than in NC women. Cord BDNF levels at delivery in women with PE were 
      lower (p=0.032) than those in NC women. Placental BDNF gene expression was also 
      lower (p=0.0082) in women with PE than in NC women. Our data suggests that BDNF 
      plays an important role in the development of the materno-fetal-placental unit 
      during pregnancy. Alteration in the levels of BDNF during pregnancy may be 
      associated with an abnormal development of the placenta resulting in PE.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - D'Souza, Vandita
AU  - D'Souza V
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune, India.
FAU - Patil, Vidya
AU  - Patil V
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune, India.
FAU - Pisal, Hemlata
AU  - Pisal H
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune, India.
FAU - Randhir, Karuna
AU  - Randhir K
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune, India.
FAU - Joshi, Asmita
AU  - Joshi A
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune, India.
FAU - Mehendale, Savita
AU  - Mehendale S
AD  - Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, 
      Bharati Vidyapeeth University, Pune, India.
FAU - Wagh, Girija
AU  - Wagh G
AD  - Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, 
      Bharati Vidyapeeth University, Pune, India.
FAU - Gupte, Sanjay
AU  - Gupte S
AD  - Gupte Hospital and Research Centre, Pune, India.
FAU - Joshi, Sadhana
AU  - Joshi S
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune, India. Electronic address: 
      srjoshi62@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140620
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fetal Blood/metabolism
MH  - Fetus/*metabolism
MH  - Gestational Age
MH  - Humans
MH  - Longitudinal Studies
MH  - Placenta/*metabolism
MH  - Pre-Eclampsia/*metabolism/*pathology
MH  - Pregnancy
MH  - RNA, Messenger/metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Brain derived neurotrophic factor
OT  - Placental development
OT  - Preeclampsia
OT  - Pregnancy
EDAT- 2014/06/24 06:00
MHDA- 2015/04/15 06:00
CRDT- 2014/06/24 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/06/13 00:00 [revised]
PHST- 2014/06/13 00:00 [accepted]
PHST- 2014/06/24 06:00 [entrez]
PHST- 2014/06/24 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - S0736-5748(14)00090-2 [pii]
AID - 10.1016/j.ijdevneu.2014.06.008 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2014 Oct;37:36-40. doi: 10.1016/j.ijdevneu.2014.06.008. Epub 
      2014 Jun 20.