PMID- 24957212
OWN - NLM
STAT- MEDLINE
DCOM- 20150630
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 37
IP  - 9
DP  - 2014 Sep
TI  - Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible 
      factor-1.
PG  - 637-43
LID - 10.14348/molcells.2014.0150 [doi]
AB  - Wound healing is a complex multi-step process that requires spatial and temporal 
      orchestration of cellular and non-cellular components. Hypoxia is one of the 
      prominent microenvironmental factors in tissue injury and wound healing. Hypoxic 
      responses, mainly mediated by a master transcription factor of oxygen 
      homeostasis, hypoxia-inducible factor-1 (HIF-1), have been shown to be critically 
      involved in virtually all processes of wound healing and remodeling. Yet, 
      mechanisms underlying hypoxic regulation of wound healing are still poorly 
      understood. Better understanding of how the wound healing process is regulated by 
      the hypoxic microenvironment and HIF-1 signaling pathway will provide insight 
      into the development of a novel therapeutic strategy for impaired wound healing 
      conditions such as diabetic wound and fibrosis. In this review, we will discuss 
      recent studies illuminating the roles of HIF-1 in physiologic and pathologic 
      wound repair and further, the therapeutic potentials of HIF-1 stabilization or 
      inhibition.
FAU - Ruthenborg, Robin J
AU  - Ruthenborg RJ
AD  - Department of Molecular and Cell Biology, The University of Texas at Dallas, 
      Richardson TX 75080, USA.
FAU - Ban, Jae-Jun
AU  - Ban JJ
AD  - Department of Molecular and Cell Biology, The University of Texas at Dallas, 
      Richardson TX 75080, USA.
FAU - Wazir, Anum
AU  - Wazir A
AD  - Department of Molecular and Cell Biology, The University of Texas at Dallas, 
      Richardson TX 75080, USA.
FAU - Takeda, Norihiko
AU  - Takeda N
AD  - Department of Molecular and Cell Biology, The University of Texas at Dallas, 
      Richardson TX 75080, USA.
FAU - Kim, Jung-Whan
AU  - Kim JW
AD  - Department of Molecular and Cell Biology, The University of Texas at Dallas, 
      Richardson TX 75080, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140624
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Animals
MH  - Cell Hypoxia/physiology
MH  - Diabetes Mellitus/physiopathology
MH  - Fibrosis/metabolism
MH  - Humans
MH  - Hypoxia/metabolism
MH  - Hypoxia-Inducible Factor 1/*physiology
MH  - Signal Transduction
MH  - Wound Healing/*physiology
PMC - PMC4179131
OTO - NOTNLM
OT  - fibrosis
OT  - hypoxia
OT  - hypoxia-inducible factor-1
OT  - oxygen
OT  - wound healing
EDAT- 2014/06/25 06:00
MHDA- 2015/07/01 06:00
PMCR- 2014/06/24
CRDT- 2014/06/25 06:00
PHST- 2014/06/05 00:00 [received]
PHST- 2014/06/08 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/07/01 06:00 [medline]
PHST- 2014/06/24 00:00 [pmc-release]
AID - S1016-8478(23)05355-4 [pii]
AID - molcell-37-9-637 [pii]
AID - 10.14348/molcells.2014.0150 [doi]
PST - ppublish
SO  - Mol Cells. 2014 Sep;37(9):637-43. doi: 10.14348/molcells.2014.0150. Epub 2014 Jun 
      24.