PMID- 24957361
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20220408
IS  - 1128-045X (Electronic)
IS  - 1123-6337 (Linking)
VI  - 18
IP  - 8
DP  - 2014 Aug
TI  - Ligation of intersphincteric fistula tract (LIFT) to treat anal fistula: 
      systematic review and meta-analysis.
PG  - 685-91
LID - 10.1007/s10151-014-1183-3 [doi]
AB  - Sphincter-preserving approaches to treat anal fistula do not jeopardize 
      continence; however, healing rates are suboptimal. In this context, ligation of 
      the intersphincteric fistula tract (LIFT) can be considered promising offering 
      high success rates and a relatively simple procedure. This review aimed to 
      investigate the outcomes of LIFT to treat anal fistula. We conducted a systematic 
      review of the Pubmed, Web of Science, and Cochrane databases, to retrieve all 
      relevant scientific original articles and scientific abstracts (Web of Science) 
      related to the LIFT procedure for anal fistula between January 2007 and March 
      2013. The search yielded 24 original articles including 1,110 patients; these 
      included one randomized controlled study, three case control studies, and 20 case 
      series. Most studies included patients with trans-sphincteric or complex fistula, 
      not amenable to fistulotomy. During a pooled mean 10.3 months of follow-up, the 
      mean success, incontinence, intraoperative, and postoperative complication rates 
      were 76.4, 0, 0, and 5.5%, respectively. A sensitivity analysis showed that the 
      impact on success in terms of follow-up duration, study size, and combining other 
      procedures was limited. There was no association between pre-LIFT drainage seton 
      and success of LIFT. Ligation of the intersphincteric fistula tract appears to be 
      an effective and safe treatment for trans-sphincteric or complex anal fistula. 
      Combining other procedures and a pre-LIFT drainage seton does not seem to confer 
      any added benefit in terms of success. However, given the lack of prospective 
      randomized trials, interpretation of these data must be cautious. Further trials 
      are mandatory to identify predictive factors for success, and true effectiveness 
      of the LIFT compared to other sphincter-preserving procedures to treat anal 
      fistula.
FAU - Hong, K D
AU  - Hong KD
AD  - Department of colorectal surgery, Korea University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kang, S
AU  - Kang S
FAU - Kalaskar, S
AU  - Kalaskar S
FAU - Wexner, S D
AU  - Wexner SD
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140624
PL  - Italy
TA  - Tech Coloproctol
JT  - Techniques in coloproctology
JID - 9613614
SB  - IM
MH  - Anal Canal/*surgery
MH  - Digestive System Surgical Procedures/*methods
MH  - Humans
MH  - Ligation/methods
MH  - Rectal Fistula/*surgery
EDAT- 2014/06/25 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/06/25 06:00
PHST- 2013/12/09 00:00 [received]
PHST- 2014/03/12 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1007/s10151-014-1183-3 [doi]
PST - ppublish
SO  - Tech Coloproctol. 2014 Aug;18(8):685-91. doi: 10.1007/s10151-014-1183-3. Epub 
      2014 Jun 24.