PMID- 24957783
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20220409
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Print)
IS  - 1465-9921 (Linking)
VI  - 15
IP  - 1
DP  - 2014 Jun 23
TI  - Derivation of normative data for the COPD assessment test (CAT).
PG  - 68
LID - 10.1186/1465-9921-15-68 [doi]
AB  - BACKGROUND: The tradition classification of the severity of COPD, based on 
      spirometry, fails to encompass the heterogeneity of the disease. The COPD 
      assessment test (CAT), a multi-dimensional, patient-filled questionnaire, 
      assesses the overall health status of patients, and is recommended as part of the 
      assessment of individuals with COPD. However, information regarding the range of 
      values for the test in a non-COPD population (normative values) is limited, and 
      consequently, knowledge regarding the optimal cut-off, and the minimum clinically 
      important difference (MCID) for the test remain largely empirical. METHODS: 
      CanCOLD is a population-based multi-center cohort study conducted across Canada, 
      the methodology of which is based on the international BOLD initiative. The study 
      includes subjects with COPD, at-risk individuals who smoke, and healthy control 
      subjects. CAT questionnaires were administered at baseline to all subjects. Among 
      non-COPD subjects, normative values for the CAT questionnaire, and psychometric 
      properties of the test were characterized. Predictors of high CAT scores were 
      identified using multivariable logistic regression. RESULTS: Of the 525 non-COPD 
      subjects enrolled, 500 were included in the analysis. Mean FEV1/FVC ratio among 
      the 500 included subjects was 0.77 (SD 0.49); the mean predicted FEV1 was 99.38% 
      (SD 16.88%). The overall mean CAT score was 6 (SD 5.09); scores were higher among 
      females (6.43, SD 5.59), and subjects over 80 years of age (mean 7.58, SD 6.82). 
      Cronbach alpha for the CAT was 0.79, suggesting a high internal consistency for 
      the test. A score of 16 was the 95th percentile for the population, and 27 
      subjects (5.4%) were found to have a CAT score > =16. Current smoking (aOR 3.41, 
      95% CI 1.05, 11.02), subject-reported physician-diagnosed asthma (aOR 7.59, 95% 
      CI 2.71, 21.25) and musculoskeletal disease (aOR 4.09, 95% CI 1.72, 9.71) were 
      found to be significantly associated with a score >/=16. CONCLUSIONS: The 
      characterization of CAT scores in the general population will be useful for 
      norm-based comparisons. Longitudinal follow-up of these subjects will help in the 
      optimization of cut-offs for the test.
FAU - Pinto, Lancelot M
AU  - Pinto LM
FAU - Gupta, Nisha
AU  - Gupta N
FAU - Tan, Wan
AU  - Tan W
FAU - Li, Pei Z
AU  - Li PZ
FAU - Benedetti, Andrea
AU  - Benedetti A
FAU - Jones, Paul W
AU  - Jones PW
FAU - Bourbeau, Jean
AU  - Bourbeau J
AD  - Respiratory Epidemiology and Clinical Research Unit, McGill University Health 
      Centre, Montreal, Quebec, Canada. jean.bourbeau@mcgill.ca.
CN  - CanCOLD study group
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140623
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Canada/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/*epidemiology
MH  - Statistics as Topic/*methods
MH  - *Surveys and Questionnaires/standards
PMC - PMC4100027
EDAT- 2014/06/25 06:00
MHDA- 2015/04/18 06:00
PMCR- 2014/06/23
CRDT- 2014/06/25 06:00
PHST- 2014/02/19 00:00 [received]
PHST- 2014/06/04 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
PHST- 2014/06/23 00:00 [pmc-release]
AID - 1465-9921-15-68 [pii]
AID - 10.1186/1465-9921-15-68 [doi]
PST - epublish
SO  - Respir Res. 2014 Jun 23;15(1):68. doi: 10.1186/1465-9921-15-68.