PMID- 24958166
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220321
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 78
IP  - 4
DP  - 2014 Aug
TI  - Use of proton pump inhibitors (PPI) and history of earlier fracture are 
      independent risk factors for fracture in postmenopausal women. The WHILA study.
PG  - 310-5
LID - S0378-5122(14)00183-2 [pii]
LID - 10.1016/j.maturitas.2014.05.019 [doi]
AB  - Postmenopausal women in the Western world are highly burdened by osteoporotic 
      fractures. The aim of this study is to investigate risk factors at baseline for 
      fracture in 6416 postmenopausal women during long-term follow-up. At baseline, 
      all women completed a questionnaire regarding background factors, diseases, 
      current use of medications and reproductive and contraceptive history, a physical 
      examination and laboratory analyses. Fracture occurrence after inclusion in the 
      study was recorded with the help of official registries. All significant 
      variables in univariate logistic regression with a decreased or increased risk 
      for fracture were analysed in a multivariate logistic regression. Increased 
      fracture risk was observed in women currently using proton pump inhibitors (PPI), 
      odds ratio (OR) 2.53 (95% confidence interval (CI)) 1.28-4.99, and women having 
      had a fracture after the age of 40, but before inclusion in the study, OR 1.70 
      (95% CI 1.24-2.32). A protective effect against fractures was observed in women 
      with a positive family history of diabetes OR 0.66 (95% CI 0.44-0.98). A 
      significant interaction was observed between fracture risk, use of PPI and HT 
      status (p=0.014) and women with HT had an increased fracture risk with use of PPI 
      (OR 3.37 (95% CI 1.96-5.80)) compared to women without HT (OR 1.13 (95% CI 
      0.57-2.24)). In conclusion, usage of PPIs was associated with a doubled risk for 
      fracture in postmenopausal women. Women with previous fractures using PPI should 
      be considered for prophylactic treatment reducing fracture risk.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Moberg, Louise M E
AU  - Moberg LM
AD  - Clinical Sciences, Department of Obstetrics and Gynaecology, Skane University 
      Hospital, Lund University, SE-221 85 Lund, Sweden. Electronic address: 
      louise.moberg@med.lu.se.
FAU - Nilsson, Peter M
AU  - Nilsson PM
AD  - Clinical Sciences, Department of Obstetrics and Gynaecology, Skane University 
      Hospital, Lund University, SE-221 85 Lund, Sweden. Electronic address: 
      peter.nilsson@med.lu.se.
FAU - Samsioe, Goran
AU  - Samsioe G
AD  - Clinical Sciences, Department of Obstetrics and Gynaecology, Skane University 
      Hospital, Lund University, SE-221 85 Lund, Sweden. Electronic address: 
      goran.samsioe@hotmail.com.
FAU - Borgfeldt, Christer
AU  - Borgfeldt C
AD  - Clinical Sciences, Department of Obstetrics and Gynaecology, Skane University 
      Hospital, Lund University, SE-221 85 Lund, Sweden. Electronic address: 
      christer.borgfeldt@med.lu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140602
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - *Bone Density
MH  - Diabetes Mellitus
MH  - Estrogen Replacement Therapy
MH  - Female
MH  - Fractures, Bone/complications
MH  - Humans
MH  - Logistic Models
MH  - Middle Aged
MH  - Odds Ratio
MH  - Osteoporosis, Postmenopausal/*complications
MH  - Osteoporotic Fractures/*etiology
MH  - Postmenopause
MH  - Protective Factors
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Registries
MH  - Risk Factors
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Bone mineral density (BMD)
OT  - Fracture risk
OT  - Postmenopausal women
OT  - Previous fracture
OT  - Proton pump inhibitors (PPI)
EDAT- 2014/06/25 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/25 06:00
PHST- 2013/11/21 00:00 [received]
PHST- 2014/05/21 00:00 [revised]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S0378-5122(14)00183-2 [pii]
AID - 10.1016/j.maturitas.2014.05.019 [doi]
PST - ppublish
SO  - Maturitas. 2014 Aug;78(4):310-5. doi: 10.1016/j.maturitas.2014.05.019. Epub 2014 
      Jun 2.