PMID- 24958218
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20190918
IS  - 1875-5607 (Electronic)
IS  - 1389-5575 (Linking)
VI  - 14
IP  - 7
DP  - 2014
TI  - Novel drug delivery systems for releasing growth factors to the CNS: focus on 
      Alzheimer's and Parkinson's diseases.
PG  - 557-66
AB  - Alzheimer's disease (AD) and Parkinson's disease (PD) represent the most common 
      neurodegenerative disorders and affect more than 35 million people. Due to the 
      limited effectiveness of available treatments in halting the neurodegenerative 
      process, new therapies, such therapies based on growth factors (GFs), have been 
      investigated. Nevertheless, the efficacies of these new treatments depend not 
      only on the application of neurotrophins but also on the approaches used to 
      deliver these proteins such that they can reach the brain. This review summarises 
      the most widely used drug delivery systems (DDSs) for releasing GFs as possible 
      treatments for AD and PD.
FAU - Herran, E
AU  - Herran E
FAU - Igartua, M
AU  - Igartua M
FAU - Pedraz, J L
AU  - Pedraz JL
FAU - Hernandez, R M
AU  - Hernandez RM
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country 
      (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, 
      Spain. rosa.hernandez@ehu.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mini Rev Med Chem
JT  - Mini reviews in medicinal chemistry
JID - 101094212
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Alzheimer Disease/*metabolism/therapy
MH  - Animals
MH  - Central Nervous System/*metabolism
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*administration & 
      dosage/*pharmacokinetics/therapeutic use
MH  - Parkinson Disease/*metabolism/therapy
EDAT- 2014/06/25 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/25 06:00
PHST- 2014/03/31 00:00 [received]
PHST- 2014/05/23 00:00 [revised]
PHST- 2014/06/18 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - MRMC-EPUB-61094 [pii]
AID - 10.2174/1389557514666140622205058 [doi]
PST - ppublish
SO  - Mini Rev Med Chem. 2014;14(7):557-66. doi: 10.2174/1389557514666140622205058.