PMID- 24958494
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20211021
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 265
IP  - 2
DP  - 2015 Mar
TI  - Influence of DGKH variants on amygdala volume in patients with bipolar affective 
      disorder and schizophrenia.
PG  - 127-36
LID - 10.1007/s00406-014-0513-9 [doi]
AB  - The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide 
      association study, is one of the few replicated risk genes of bipolar affective 
      disorder (BD). Following initial positive studies, it not only was found to be 
      associated with BD but also implicated in the etiology of other psychiatric 
      disorders featuring affective symptoms, rendering DGKH a cross-disorder risk 
      gene. However, the (patho-)physiological role of the encoded enzyme is still 
      elusive. In the present study, we investigated primarily the influence of a risk 
      haplotype on amygdala volume in patients suffering from schizophrenia or BD as 
      well as healthy controls and four single nucleotide polymorphisms conveying risk. 
      There was a significant association of the DGKH risk haplotype with increased 
      amygdala volume in BD, but not in schizophrenia or healthy controls. These 
      findings add to the notion of a role of DGKH in the pathogenesis of BD.
FAU - Kittel-Schneider, S
AU  - Kittel-Schneider S
AD  - Psychiatric Neurobiology and Bipolar Disorder Program, Department of Psychiatry, 
      Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr. 15, 
      97080, Wurzburg, Germany, Kittel_S@klinik.uni-wuerzburg.de.
FAU - Wobrock, T
AU  - Wobrock T
FAU - Scherk, H
AU  - Scherk H
FAU - Schneider-Axmann, T
AU  - Schneider-Axmann T
FAU - Trost, S
AU  - Trost S
FAU - Zilles, D
AU  - Zilles D
FAU - Wolf, C
AU  - Wolf C
FAU - Schmitt, A
AU  - Schmitt A
FAU - Malchow, B
AU  - Malchow B
FAU - Hasan, A
AU  - Hasan A
FAU - Backens, M
AU  - Backens M
FAU - Reith, W
AU  - Reith W
FAU - Falkai, P
AU  - Falkai P
FAU - Gruber, O
AU  - Gruber O
FAU - Reif, A
AU  - Reif A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140624
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - EC 2.7.1.107 (DGKZ protein, human)
RN  - EC 2.7.1.107 (Diacylglycerol Kinase)
SB  - IM
MH  - Adult
MH  - Amygdala/*pathology
MH  - Bipolar Disorder/*genetics/*pathology
MH  - DNA Mutational Analysis
MH  - Diacylglycerol Kinase/*genetics
MH  - Female
MH  - Functional Laterality
MH  - Gene Frequency
MH  - Haplotypes
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*genetics/*pathology
MH  - Statistics, Nonparametric
EDAT- 2014/06/25 06:00
MHDA- 2015/11/13 06:00
CRDT- 2014/06/25 06:00
PHST- 2014/01/18 00:00 [received]
PHST- 2014/06/03 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - 10.1007/s00406-014-0513-9 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2015 Mar;265(2):127-36. doi: 
      10.1007/s00406-014-0513-9. Epub 2014 Jun 24.