PMID- 24958906 OWN - NLM STAT- MEDLINE DCOM- 20150129 LR - 20161125 IS - 1462-0332 (Electronic) IS - 1462-0324 (Linking) VI - 53 IP - 12 DP - 2014 Dec TI - Bone and cartilage metabolism markers in synovial fluid of the hip joint with secondary osteoarthritis. PG - 2191-5 LID - 10.1093/rheumatology/keu253 [doi] AB - OBJECTIVE: The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis (RDA) and developmental dysplasia of the hip (DDH). METHODS: We studied 70 synovial fluid samples obtained from 57 patients with ONFH (mean age 46 years, 34 males, 23 females), 21 samples obtained from 21 patients with RDA (mean age 70 years, 2 males, 19 females) and 20 samples obtained from 20 patients with DDH (mean age 56 years, 2 males, 18 females). The levels of bone alkaline phosphatase (BAP) and tartrate-resistant acid phosphatase 5b (TRACP-5b), as bone metabolism markers, and matrix metalloproteinase 3 (MMP-3) and keratan sulphate (KS), as cartilage metabolism markers, were analysed. RESULTS: The levels of BAP, MMP-3 and KS were significantly higher in the ONFH group than in the RDA and DDH groups. The levels of TRACP-5b were highest in the RDA group. The levels of BAP in the ONFH group after the development of osteoarthritic changes were significantly lower than those observed in earlier stages. In comparisons between the samples obtained from each group with a terminal condition, the ONFH samples exhibited significantly higher MMP-3 and KS levels, while the TRACP-5 levels were highest in the RDA group. CONCLUSION: The ONFH patients showed a relatively bone formative condition before the osteoarthritic stage and maintained a higher rate of cartilage turnover throughout several stages compared with the RDA and DDH patients. RDA patients were characterized by a significantly high osteoclast activity. CI - (c) The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Yamaguchi, Ryosuke AU - Yamaguchi R AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Yamamoto, Takuaki AU - Yamamoto T AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. yamataku@ortho.med.kyushu-u.ac.jp. FAU - Motomura, Goro AU - Motomura G AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Ikemura, Satoshi AU - Ikemura S AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Iwasaki, Kenyu AU - Iwasaki K AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Zhao, Garida AU - Zhao G AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Doi, Toshio AU - Doi T AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Iwamoto, Yukihide AU - Iwamoto Y AD - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140623 PL - England TA - Rheumatology (Oxford) JT - Rheumatology (Oxford, England) JID - 100883501 RN - 0 (Biomarkers) RN - 0 (Isoenzymes) RN - 9056-36-4 (Keratan Sulfate) RN - EC 3.1.3.1 (Alkaline Phosphatase) RN - EC 3.1.3.2 (ACP5 protein, human) RN - EC 3.1.3.2 (Acid Phosphatase) RN - EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase) RN - EC 3.4.24.17 (Matrix Metalloproteinase 3) SB - IM MH - Acid Phosphatase/metabolism MH - Adult MH - Aged MH - Alkaline Phosphatase/metabolism MH - Biomarkers/metabolism MH - Cartilage, Articular/*metabolism MH - Female MH - Femur Head Necrosis/complications/metabolism MH - Hip Dislocation, Congenital/complications/metabolism MH - Humans MH - Isoenzymes/metabolism MH - Keratan Sulfate/metabolism MH - Male MH - Matrix Metalloproteinase 3/metabolism MH - Middle Aged MH - Osteoarthritis, Hip/etiology/*metabolism MH - Synovial Fluid/*metabolism MH - Tartrate-Resistant Acid Phosphatase MH - Young Adult OTO - NOTNLM OT - bone metabolism marker OT - cartilage metabolism marker OT - developmental dysplasia of the hip OT - hip osteoarthritis OT - osteonecrosis of the femoral head OT - rapidly destructive arthrosis OT - synovial fluid analysis EDAT- 2014/06/25 06:00 MHDA- 2015/01/30 06:00 CRDT- 2014/06/25 06:00 PHST- 2014/06/25 06:00 [entrez] PHST- 2014/06/25 06:00 [pubmed] PHST- 2015/01/30 06:00 [medline] AID - keu253 [pii] AID - 10.1093/rheumatology/keu253 [doi] PST - ppublish SO - Rheumatology (Oxford). 2014 Dec;53(12):2191-5. doi: 10.1093/rheumatology/keu253. Epub 2014 Jun 23.