PMID- 24959251
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 8
IP  - 1
DP  - 2014 Jul
TI  - Multiple endocrine neoplasia type 1 associated with breast cancer: A case report 
      and review of the literature.
PG  - 230-234
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a cancer predisposition syndrome 
      that includes a combination of endocrine and non-endocrine tumors. The present 
      study reports a rare case of MEN1 associated with breast cancer with the MEN1 
      gene mutation. A 45-year-old female was diagnosed with breast cancer subsequent 
      to presenting with a right breast mass. Pre-operative radiological studies 
      indicated right breast cancer with a suspicious metastatic nodule of the lung. 
      Further studies demonstrated bilateral thyroid nodules, a neuroendocrine tumor of 
      the pancreas, paraganglioma, a left adrenal adenoma, gallstones, uterine 
      subserosal myoma and pituitary macroadenoma. Laboratory examinations revealed 
      hypercalcemia, hypophosphatemia and an increased intact parathyroid hormone 
      level. The workup for the suspected MEN syndrome revealed an increased basal 
      plasma level of insulin-like growth factor-1, prolactin and calcitonin, and an 
      increased 24-h urinary free cortisol level. The patient underwent surgical 
      removal of the breast cancer and the tumors of the pancreas, adrenal gland, 
      thyroid and parathyroid glands, uterus, anterior mediastinum and lung. The 
      pathological diagnosis of the resected breast was of invasive ductal carcinoma. 
      Otherwise the pathological diagnosis was of calcitonin-producing pancreatic 
      endocrine carcinoma, adrenal cortical adenoma, bilateral papillary thyroid 
      carcinomas, parathyroid adenomas, uterine leiomyoma with adenomyosis, a thymic 
      carcinoid tumor and lung hamatoma. Gene analysis was performed to determine the 
      association between gene mutations and the development of tumors in this patient, 
      and a germ-line MEN1 gene mutation was consequently detected. It could be assumed 
      that MEN1 syndrome may have possibly predisposed the present patient to breast 
      cancer. However, additional observations and further studies are required to 
      demonstrate this association.
FAU - Jeong, Young Ju
AU  - Jeong YJ
AD  - Department of Surgery, College of Medicine, Catholic University of Daegu, Nam-gu, 
      Daegu 705-718, Republic of Korea.
FAU - Oh, Hoon Kyu
AU  - Oh HK
AD  - Department of Pathology, College of Medicine, Catholic University of Daegu, 
      Nam-gu, Daegu 705-718, Republic of Korea.
FAU - Bong, Jin Gu
AU  - Bong JG
AD  - Department of Surgery, College of Medicine, Catholic University of Daegu, Nam-gu, 
      Daegu 705-718, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20140513
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4063580
OTO - NOTNLM
OT  - MEN1 gene
OT  - breast cancer
OT  - multiple endocrine neoplasia type 1 (MEN1)
OT  - pancreatic endocrine carcinoma
OT  - primary hyperparathyroidism
EDAT- 2014/06/25 06:00
MHDA- 2014/06/25 06:01
PMCR- 2014/05/13
CRDT- 2014/06/25 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2014/04/03 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2014/06/25 06:01 [medline]
PHST- 2014/05/13 00:00 [pmc-release]
AID - ol-08-01-0230 [pii]
AID - 10.3892/ol.2014.2144 [doi]
PST - ppublish
SO  - Oncol Lett. 2014 Jul;8(1):230-234. doi: 10.3892/ol.2014.2144. Epub 2014 May 13.