PMID- 24960295
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20141013
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 69
IP  - 5
DP  - 2014 Nov
TI  - Bloodstream infections in neutropenic patients with cancer: differences between 
      patients with haematological malignancies and solid tumours.
PG  - 417-23
LID - S0163-4453(14)00171-6 [pii]
LID - 10.1016/j.jinf.2014.05.018 [doi]
AB  - OBJECTIVES: We sought to identify the characteristics, aetiology, antibiotic 
      resistance and outcomes of bloodstream infection (BSI) in neutropenic patients 
      with haematological malignancies (HM) and in those with solid tumours (ST) and 
      assess their impact on empirical therapy and outcomes. METHODS: All episodes of 
      BSI in neutropenic patients with HM and ST were prospectively recorded and 
      compared. RESULTS: Of 579 episodes of BSI, 493 occurred in patients with HM and 
      86 in patients with ST. An endogenous source and catheter-related infection were 
      more frequent in patients with HM, whereas pneumonia and urinary tract were more 
      common in the ST group. BSI was mainly due to Gram-negative bacilli. 
      Coagulase-negative staphylococci were more frequent in patients with HM, while 
      Pseudomonas aeruginosa was more common in patients with ST and was the leading 
      cause of pneumonia. Multidrug-resistant Gram-negative bacilli (MDRGNB) were more 
      frequently isolated in haematological patients who more often received inadequate 
      empirical therapy than those with ST. Case-fatality rates were higher in patients 
      with ST. CONCLUSIONS: We identified significant differences in BSI in neutropenic 
      patients with HM and ST. MDRGNB were more often isolated in patients with HM. 
      Pneumonia due to P. aeruginosa was particularly frequent among patients with ST. 
      Case-fatality rates were higher in patients with ST.
CI  - Copyright (c) 2014 The British Infection Association. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Marin, Mar
AU  - Marin M
AD  - Oncology Department, ICO (Institut Catala d'Oncologia) l'Hospitalet, ICO Duran i 
      Reynals, University of Barcelona, Barcelona, Spain. Electronic address: 
      mmarin@iconcologia.net.
FAU - Gudiol, Carlota
AU  - Gudiol C
AD  - Infectious Disease Service, Institut d'Investigacio Biomedica de Bellvitge 
      (IDIBELL), Hospital Universitari de Bellvitge, University of Barcelona, Spain; 
      REIPI (Spanish Network for Research in Infectious Disease), Instituto de Salud 
      Carlos III, Madrid, Spain.
FAU - Ardanuy, Carmen
AU  - Ardanuy C
AD  - Microbiology Department, Institut d'Investigacio Biomedica de Bellvitge 
      (IDIBELL), Hospital Universitari de Bellvitge, University of Barcelona, Spain; 
      CIBERes (Centro de Investigacion Biomedica en Red en Enfermedades Respiratorias), 
      Instituto de Salud Carlos III, Spain.
FAU - Garcia-Vidal, Carol
AU  - Garcia-Vidal C
AD  - Infectious Disease Service, Institut d'Investigacio Biomedica de Bellvitge 
      (IDIBELL), Hospital Universitari de Bellvitge, University of Barcelona, Spain; 
      REIPI (Spanish Network for Research in Infectious Disease), Instituto de Salud 
      Carlos III, Madrid, Spain.
FAU - Calvo, Mariona
AU  - Calvo M
AD  - Oncology Department, ICO (Institut Catala d'Oncologia) l'Hospitalet, ICO Duran i 
      Reynals, University of Barcelona, Barcelona, Spain.
FAU - Arnan, Montserrat
AU  - Arnan M
AD  - Haematology Department, ICO (Institut Catala d'Oncologia) l'Hospitalet, ICO Duran 
      i Reynals, Barcelona, Spain; Institut d'InvestigacioBiomedica de Bellvitge 
      (IDIBELL), University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
FAU - Carratala, Jordi
AU  - Carratala J
AD  - Infectious Disease Service, Institut d'Investigacio Biomedica de Bellvitge 
      (IDIBELL), Hospital Universitari de Bellvitge, University of Barcelona, Spain; 
      REIPI (Spanish Network for Research in Infectious Disease), Instituto de Salud 
      Carlos III, Madrid, Spain.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140621
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Bacteremia/drug therapy/*microbiology
MH  - Drug Resistance, Bacterial
MH  - Female
MH  - Gram-Negative Bacteria/drug effects/isolation & purification
MH  - Gram-Negative Bacterial Infections/drug therapy/*microbiology
MH  - Gram-Positive Bacterial Infections/drug therapy/*microbiology
MH  - Hematologic Neoplasms/*complications/microbiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications/microbiology
MH  - Neutropenia/*complications/microbiology
MH  - Pneumonia/drug therapy/microbiology
MH  - Pseudomonas Infections/drug therapy/microbiology
MH  - Pseudomonas aeruginosa/drug effects/isolation & purification
MH  - Young Adult
OTO - NOTNLM
OT  - Bacteraemia
OT  - Bloodstream infection
OT  - Cancer
OT  - Neutropenia
OT  - Solid tumour
EDAT- 2014/06/25 06:00
MHDA- 2015/07/07 06:00
CRDT- 2014/06/25 06:00
PHST- 2014/02/04 00:00 [received]
PHST- 2014/05/05 00:00 [revised]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/06/25 06:00 [entrez]
PHST- 2014/06/25 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
AID - S0163-4453(14)00171-6 [pii]
AID - 10.1016/j.jinf.2014.05.018 [doi]
PST - ppublish
SO  - J Infect. 2014 Nov;69(5):417-23. doi: 10.1016/j.jinf.2014.05.018. Epub 2014 Jun 
      21.