PMID- 24961518
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140625
LR  - 20211021
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 3
IP  - 3
DP  - 2013 Jun 25
TI  - Neuroprotective role of nerve growth factor in hypoxic-ischemic brain injury.
PG  - 1013-22
LID - 10.3390/brainsci3031013 [doi]
AB  - Hypoxic-ischemic brain injuries (HIBI) in childhood are frequently associated 
      with poor clinical and neurological outcome. Unfortunately, there is currently no 
      effective therapy to restore neuronal loss and to determine substantial clinical 
      improvement. Several neurotrophins, such as Nerve Growth Factor (NGF), 
      Brain-Derived Neurotrophic Factor (BDNF), and Glial Derived Neurotrophic Factor 
      (GDNF), play a key role in the development, differentiation, and survival of the 
      neurons of the peripheral and central nervous system. Experimental animal studies 
      demonstrated their neuroprotective role in HIBI, while only a few studies 
      examined the neuroprotective mechanisms in patients with severe HIBI. We report 
      two cases of children with HIBI and prolonged comatose state who showed a 
      significant improvement after intraventricular NGF administration characterized 
      by amelioration of electroencephalogram (EEG) and cerebral perfusion at 
      single-photon emission computed tomography (SPECT). The improvement in motor and 
      cognitive functions of these children could be related to the neuroprotective 
      role exerted by NGF in residual viable cholinergic neurons, leading to the 
      restoration of neuronal networks in the damaged brain.
FAU - Fantacci, Claudia
AU  - Fantacci C
AD  - Department of Pediatric Neuroscience, Catholic University of Rome, Largo A. 
      Gemelli 8, Rome 00168, Italy. claudiafantacci@yahoo.it.
FAU - Capozzi, Domenico
AU  - Capozzi D
AD  - Department of Pediatric Neuroscience, Catholic University of Rome, Largo A. 
      Gemelli 8, Rome 00168, Italy. dcapozzi@hotmail.it.
FAU - Ferrara, Pietro
AU  - Ferrara P
AD  - Department of Pediatric Neuroscience, Catholic University of Rome, Largo A. 
      Gemelli 8, Rome 00168, Italy. pferrara@rm.unicatt.it.
FAU - Chiaretti, Antonio
AU  - Chiaretti A
AD  - Department of Pediatric Neuroscience, Catholic University of Rome, Largo A. 
      Gemelli 8, Rome 00168, Italy. achiaretti@yahoo.it.
LA  - eng
PT  - Journal Article
DEP - 20130625
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC4061878
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/09/01
CRDT- 2014/06/26 06:00
PHST- 2013/05/17 00:00 [received]
PHST- 2013/06/02 00:00 [revised]
PHST- 2013/06/07 00:00 [accepted]
PHST- 2014/06/26 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - brainsci3031013 [pii]
AID - brainsci-03-01013 [pii]
AID - 10.3390/brainsci3031013 [doi]
PST - epublish
SO  - Brain Sci. 2013 Jun 25;3(3):1013-22. doi: 10.3390/brainsci3031013.