PMID- 24962260
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20211203
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 14
IP  - 7
DP  - 2014 Jul
TI  - Integrating canonical and metabolic signalling programmes in the regulation of T 
      cell responses.
PG  - 435-46
LID - 10.1038/nri3701 [doi]
AB  - Over the past decade, our understanding of T cell activation, differentiation and 
      function has markedly expanded, providing a greater appreciation of the signals 
      and pathways that regulate these processes. It has become clear that 
      evolutionarily conserved pathways that regulate stress responses, metabolism, 
      autophagy and survival have crucial and specific roles in regulating T cell 
      responses. Recent studies suggest that the metabolic pathways involving MYC, 
      hypoxia-inducible factor 1alpha (HIF1alpha), AMP-activated protein kinase (AMPK) and 
      mammalian target of rapamycin (mTOR) are activated upon antigen recognition and 
      that they are required for directing the consequences of T cell receptor 
      engagement. The purpose of this Review is to provide an integrated view of the 
      role of these metabolic pathways and of canonical T cell signalling pathways in 
      regulating the outcome of T cell responses.
FAU - Pollizzi, Kristen N
AU  - Pollizzi KN
AD  - Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns 
      Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
FAU - Powell, Jonathan D
AU  - Powell JD
AD  - Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns 
      Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
GR  - R01 AI091481/AI/NIAID NIH HHS/United States
GR  - T32 AI007247/AI/NIAID NIH HHS/United States
GR  - R01AI077610‑01A2/AI/NIAID NIH HHS/United States
GR  - R01 AI077610/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Myc protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/immunology
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism
MH  - Cell Differentiation/*immunology
MH  - Glycolysis
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/immunology
MH  - Immunologic Memory/immunology
MH  - Lymphocyte Activation/*immunology
MH  - Mice
MH  - Proto-Oncogene Proteins c-myc/immunology
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Signal Transduction/immunology
MH  - T-Lymphocytes, Helper-Inducer/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
MH  - TOR Serine-Threonine Kinases/immunology
PMC - PMC4390057
MID - NIHMS675478
EDAT- 2014/06/26 06:00
MHDA- 2014/10/07 06:00
PMCR- 2015/04/08
CRDT- 2014/06/26 06:00
PHST- 2014/06/26 06:00 [entrez]
PHST- 2014/06/26 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
PHST- 2015/04/08 00:00 [pmc-release]
AID - nri3701 [pii]
AID - 10.1038/nri3701 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2014 Jul;14(7):435-46. doi: 10.1038/nri3701.