PMID- 24962747
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20220330
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 3
DP  - 2014 Sep
TI  - A study of the association of childhood asthma with HLA alleles in the population 
      of Siliguri, West Bengal, India.
PG  - 316-20
LID - 10.1111/tan.12403 [doi]
AB  - Asthma is a heterogeneous disease for which a strong genetic basis is firmly 
      established. It is a complex disorder influenced by gene-environment interaction. 
      Human leukocyte antigen (HLA) genes have been shown to be consistently associated 
      with asthma and its related phenotypes in various populations. The aim of this 
      study was to determine the frequency of the selected HLA classes I and II allelic 
      groups in asthmatic and control groups. HLA typing was performed using polymerase 
      chain reaction-sequence-specific typing (PCR-SSP) method. The allele frequency 
      was estimated by direct counting. Frequency of each HLA allelic group was 
      compared between asthmatic group and control group using chi(2) test. P-value was 
      corrected by multiplying with the number of the allelic groups studied. Odds 
      ratio (OR) and its corresponding 95% confidence interval (CI) for each allelic 
      group were calculated using graphpad instat 3.10. The results of this study 
      showed a significantly higher frequency of HLA-DRB1*03 in asthmatics than in 
      controls (11.43% vs 3.64%, OR = 3.78, 95% CI = 1.61-8.85, P = 0.0025, Pcorr 
       < 0.05). Analysis of HLA alleles in low and high total serum immunoglobulin E 
      (IgE) level in asthmatics revealed no significant association. HLA-DRB1*03 may be 
      implicated in the susceptibility to asthma in the pediatric population.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lama, M
AU  - Lama M
AD  - Cellular Immunology Laboratory, Department of Zoology, University of North 
      Bengal, Siliguri, West Bengal, India; Department of Zoology, The University of 
      Burdwan, Golapbag, West Bengal, India.
FAU - Chatterjee, M
AU  - Chatterjee M
FAU - Chaudhuri, T K
AU  - Chaudhuri TK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140625
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Gene-Environment Interaction
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunity, Humoral/genetics
MH  - Immunoglobulin E/blood
MH  - India
MH  - Male
MH  - Polymorphism, Genetic
MH  - *Population Groups
OTO - NOTNLM
OT  - DRB1*03
OT  - allelic group
OT  - asthma
OT  - children
OT  - human leukocyte antigen
EDAT- 2014/06/26 06:00
MHDA- 2015/05/16 06:00
CRDT- 2014/06/26 06:00
PHST- 2014/03/05 00:00 [received]
PHST- 2014/05/02 00:00 [revised]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/06/26 06:00 [entrez]
PHST- 2014/06/26 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
AID - 10.1111/tan.12403 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Sep;84(3):316-20. doi: 10.1111/tan.12403. Epub 2014 Jun 25.