PMID- 24963088
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20150423
IS  - 1544-2217 (Electronic)
IS  - 0300-9858 (Linking)
VI  - 52
IP  - 3
DP  - 2015 May
TI  - Characterization of vascular lesions in pigs affected by porcine circovirus type 
      2-systemic disease.
PG  - 497-504
LID - 10.1177/0300985814540542 [doi]
AB  - Vascular lesions and their association with porcine circovirus type 2 (PCV2) were 
      evaluated in multiple organs from 10 pigs affected with PCV2-systemic disease 
      (PCV2-SD). Animals had vascular lesions in multiple organs, consisting of 
      lymphohistiocytic lymphangitis and/or phlebitis, mild to severe necrotizing 
      arteritis, and thrombosis within splenic arterioles and choroid plexus 
      capillaries. Variable amounts of PCV2 nucleic acid detected by in situ 
      hybridization were present within endothelial cells, tunica media myocytes, and 
      perivascular and/or intralesional inflammatory cell infiltrates. PCV2 nucleic 
      acid was detected within endothelial cells of both lymphatic and blood vessels 
      without lesions in the associated tissues. Necrotizing arteritis was principally 
      present in lymph nodes and kidney and consisted of degeneration, necrosis, and 
      pyknosis of myocytes, often with intracytoplasmic, brightly eosinophilic 
      inclusion bodies that were strongly positive for PCV2 nucleic acid. Segmental or 
      circumferential fibrinoid necrosis was mainly present in vessels of the lymph 
      node, spleen, and choroid plexus and was variably associated with PCV2 nucleic 
      acid. Severe lymphangitis associated with strong intralesional PCV2 labeling was 
      frequently detected within the mesenteric and mediastinal lymph nodes and the 
      lamina propria of the ileum. In most tissues, medium and large lymphatics and/or 
      veins often had disruption of the intima and mild mononuclear inflammatory cell 
      infiltration that was variably associated with PCV2 nucleic acid. The present 
      study indicates that vasculitis is a frequent finding in natural cases of PCV2-SD 
      and that PCV2 may have a direct cytopathic effect on tunica media myocytes of 
      small- and medium-sized arteries as well as endothelium.
CI  - (c) The Author(s) 2014.
FAU - Resendes, A R
AU  - Resendes AR
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra, Barcelona, Spain.
FAU - Segales, J
AU  - Segales J
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra, Barcelona, Spain Department de Sanitat i 
      d'Anatomia Animals, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, 
      Spain joaquim.segales@cresa.uab.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140624
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
SB  - IM
MH  - Animals
MH  - Blood Vessels/*pathology/virology
MH  - Circoviridae Infections/pathology/*veterinary/virology
MH  - *Circovirus
MH  - In Situ Hybridization/veterinary
MH  - Lymphatic Vessels/pathology/virology
MH  - Necrosis
MH  - Swine
MH  - Swine Diseases/*pathology/virology
MH  - Tunica Media/pathology/virology
OTO - NOTNLM
OT  - in situ hybridization
OT  - ischemia
OT  - lymphadenitis
OT  - porcine circovirus type 2 (PCV2)
OT  - porcine circovirus type 2-systemic disease (PCV2-SD)
OT  - swine
OT  - vasculitis
EDAT- 2014/06/26 06:00
MHDA- 2016/04/20 06:00
CRDT- 2014/06/26 06:00
PHST- 2014/06/26 06:00 [entrez]
PHST- 2014/06/26 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - 0300985814540542 [pii]
AID - 10.1177/0300985814540542 [doi]
PST - ppublish
SO  - Vet Pathol. 2015 May;52(3):497-504. doi: 10.1177/0300985814540542. Epub 2014 Jun 
      24.