PMID- 24963112
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20181202
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 37
IP  - 7
DP  - 2014 Jul
TI  - Exposure to persistent organic pollutants: relationship with abnormal glucose 
      metabolism and visceral adiposity.
PG  - 1951-8
LID - 10.2337/dc13-2329 [doi]
AB  - OBJECTIVE: The contribution of persistent organic pollutants (POPs) to the 
      pandemic of type 2 diabetes mellitus and obesity has been assumed but remains 
      speculative. Our study aimed at investigating the relationship of POP levels with 
      detailed markers of glucose metabolism and body composition. RESEARCH DESIGN AND 
      METHODS: Glucose tolerance was determined in a group of normal-weight and obese 
      individuals. Fat distribution was assessed with abdominal computed tomography 
      (CT) scanning, determining subcutaneous adipose tissue (SAT) and visceral adipose 
      tissue (VAT). Selected POPs (28 polychlorinated biphenyls [PCBs] and the 
      pesticide p,p'-dichlorodiphenyldichloroethylene [p,p'-DDE]) were measured in 
      serum. In a subset of obese individuals undergoing bariatric surgery, POPs were 
      also measured in adipose tissue. RESULTS: Among obese participants, serum and 
      adipose tissue levels of POPs were significantly correlated to glucose levels 
      during an oral glucose tolerance test. Logistic regression using a model 
      including age, age(2), sex, family history of diabetes, BMI, CT-VAT, smoking 
      behavior, physical activity level score, and a POP level identified serum levels 
      of PCB153, the sum of PCBs and p,p'-DDE as significant predictors of abnormal 
      glucose tolerance (odds ratio 4.6, 4.8, and 3.4, respectively; P < 0.05). Adipose 
      tissue levels of p,p'-DDE were also significant predictors (odds ratio 81.6; P < 
      0.05). Serum levels of PCBs were inversely related to BMI, while serum and 
      adipose tissue levels of all POPs were positively related to the CT-VAT/SAT 
      ratio, suggesting an important role for the visceral fat compartment in POP 
      dynamics. CONCLUSIONS: Our findings further sustain the theory that exposure to 
      environmentally relevant levels of POPs may exert both a diabetogenic and 
      obesogenic effect.
CI  - (c) 2014 by the American Diabetes Association.
FAU - Dirinck, Eveline L
AU  - Dirinck EL
AD  - Department of Endocrinology, Diabetology and Metabolism, Antwerp University 
      Hospital, Edegem, Belgium.
FAU - Dirtu, Alin C
AU  - Dirtu AC
AD  - Toxicology Centre, University of Antwerp, Antwerp, Belgium.
FAU - Govindan, Malarvannan
AU  - Govindan M
AD  - Toxicology Centre, University of Antwerp, Antwerp, Belgium.
FAU - Covaci, Adrian
AU  - Covaci A
AD  - Toxicology Centre, University of Antwerp, Antwerp, Belgium.
FAU - Van Gaal, Luc F
AU  - Van Gaal LF
AD  - Department of Endocrinology, Diabetology and Metabolism, Antwerp University 
      Hospital, Edegem, Belgium luc.van.gaal@uza.be.
FAU - Jorens, Philippe G
AU  - Jorens PG
AD  - Department of Clinical Pharmacology, Antwerp University Hospital, Edegem, 
      Belgium.
LA  - eng
SI  - ClinicalTrials.gov/NCT01778868
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Adiposity/*drug effects
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Composition
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Glucose/*metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Intra-Abdominal Fat/metabolism
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Obesity/*epidemiology
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Prospective Studies
MH  - Subcutaneous Fat/metabolism
MH  - Young Adult
EDAT- 2014/06/26 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/06/26 06:00
PHST- 2014/06/26 06:00 [entrez]
PHST- 2014/06/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - dc13-2329 [pii]
AID - 10.2337/dc13-2329 [doi]
PST - ppublish
SO  - Diabetes Care. 2014 Jul;37(7):1951-8. doi: 10.2337/dc13-2329.