PMID- 24963216
OWN - NLM
STAT- MEDLINE
DCOM- 20150207
LR  - 20211021
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2014
DP  - 2014
TI  - Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 
      tumor-bearing mice.
PG  - 736563
LID - 10.1155/2014/736563 [doi]
LID - 736563
AB  - Cancer-associated anorexia and cachexia are a multifactorial condition described 
      by a loss of body weight and muscle with anorexia, asthenia, and anemia. 
      Moreover, they correlate with a high mortality rate, poor response to 
      chemotherapy, poor performance status, and poor quality of life. Cancer cachexia 
      is regulated by proinflammatory cytokines such as interleukin-6 (IL-6), monocyte 
      chemoattractant protein-1 (MCP-1), and tumor necrosis factor- alpha (TNF- alpha). In 
      addition, glucagon like peptide-1 (GIP-1), peptide YY (PYY), ghrelin, and leptin 
      plays a crucial role in food intake. In this study, we investigated the 
      therapeutic effects of one of the traditional herbal medicines, Sipjeondaebo-tang 
      (Juzen-taiho-to in Japanese; SJDBT), on cancer anorexia and cachexia in a 
      fundamental mouse cancer anorexia/cachexia model, CT-26 tumor-bearing mice. SJDBT 
      was more significantly effective in a treatment model where it was treated after 
      anorexia and cachexia than in a prevention model where it was treated before 
      anorexia and cachexia on the basis of parameters such as weights of muscles and 
      whole body and food intakes. Moreover, SJDBT inhibited a production of IL-6, 
      MCP-1, PYY, and GLP-1 and ameliorated cancer-induced anemia. Therefore, our in 
      vivo studies provide evidence on the role of SJDBT in cancer-associated anorexia 
      and cachexia, thereby suggesting that SJDBT may be useful for treating 
      cancer-associated anorexia and cachexia.
FAU - Choi, Youn Kyung
AU  - Choi YK
AUID- ORCID: 0000-0001-6576-5547
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Jung, Ki Yong
AU  - Jung KY
AD  - Department of Oriental Internal Medicine, College of Oriental Medicine, Gachon 
      University, Seongnam, Republic of Korea.
FAU - Woo, Sang-Mi
AU  - Woo SM
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Yun, Yee Jin
AU  - Yun YJ
AUID- ORCID: 0000-0001-5918-1465
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Jun, Chan-Yong
AU  - Jun CY
AD  - Department of Oriental Internal Medicine, College of Oriental Medicine, Gachon 
      University, Seongnam, Republic of Korea.
FAU - Park, Jong Hyeong
AU  - Park JH
AD  - Department of Oriental Internal Medicine, College of Oriental Medicine, Gachon 
      University, Seongnam, Republic of Korea.
FAU - Shin, Yong Cheol
AU  - Shin YC
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Cho, Sung-Gook
AU  - Cho SG
AUID- ORCID: 0000-0002-8791-9532
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Ko, Seong-Gyu
AU  - Ko SG
AD  - Department of Preventive Medicine, College of Korean Medicine, Kyung Hee 
      University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140514
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Ghrelin)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Plant Preparations)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (juzentaihoto)
RN  - 106388-42-5 (Peptide YY)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Anorexia/*complications/drug therapy
MH  - Body Weight
MH  - Cachexia/*complications/drug therapy
MH  - Cell Line, Tumor
MH  - Chemokine CCL2/blood
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Ghrelin/blood
MH  - Glucagon-Like Peptide 1/blood
MH  - Inflammation
MH  - Interleukin-6/blood
MH  - Intestinal Mucosa/metabolism
MH  - Leptin/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Muscles/pathology
MH  - Neoplasm Transplantation
MH  - Neoplasms/*complications/drug therapy
MH  - Peptide YY/blood
MH  - Plant Preparations/pharmacology
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC4052064
EDAT- 2014/06/26 06:00
MHDA- 2015/02/11 06:00
PMCR- 2014/05/14
CRDT- 2014/06/26 06:00
PHST- 2014/02/17 00:00 [received]
PHST- 2014/04/23 00:00 [accepted]
PHST- 2014/06/26 06:00 [entrez]
PHST- 2014/06/26 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
PHST- 2014/05/14 00:00 [pmc-release]
AID - 10.1155/2014/736563 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2014;2014:736563. doi: 10.1155/2014/736563. Epub 2014 May 14.