PMID- 24963795
OWN - NLM
STAT- MEDLINE
DCOM- 20150601
LR  - 20211021
IS  - 1089-8611 (Electronic)
IS  - 1089-8603 (Print)
IS  - 1089-8603 (Linking)
VI  - 41
DP  - 2014 Sep 15
TI  - Homocysteine in renovascular complications: hydrogen sulfide is a modulator and 
      plausible anaerobic ATP generator.
PG  - 27-37
LID - S1089-8603(14)00251-1 [pii]
LID - 10.1016/j.niox.2014.06.006 [doi]
AB  - Homocysteine (Hcy) is a non-protein amino acid derived from dietary methionine. 
      High levels of Hcy, known as hyperhomocysteinemia (HHcy) is known to cause 
      vascular complications. In the mammalian tissue, Hcy is metabolized by 
      transsulfuration enzymes to produce hydrogen sulfide (H2S). H2S, a pungent 
      smelling gas was previously known for its toxic effects in the central nervous 
      system, recent studies however has revealed protective effects in a variety of 
      diseases including hypertension, diabetes, inflammation, atherosclerosis, and 
      renal disease progression and failure. Interestingly, under stress conditions 
      including hypoxia, H2S can reduce metabolic demand and also act as a substrate 
      for ATP production. This review highlights some of the recent advances in H2S 
      research as a potential therapeutic agent targeting renovascular diseases 
      associated with HHcy.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Sen, Utpal
AU  - Sen U
AD  - Department of Physiology and Biophysics, University of Louisville School of 
      Medicine, Louisville, KY 40292, United States. Electronic address: 
      u0sen001@louisville.edu.
FAU - Pushpakumar, Sathnur B
AU  - Pushpakumar SB
AD  - Department of Physiology and Biophysics, University of Louisville School of 
      Medicine, Louisville, KY 40292, United States.
FAU - Amin, Matthew A
AU  - Amin MA
AD  - Department of Physiology and Biophysics, University of Louisville School of 
      Medicine, Louisville, KY 40292, United States.
FAU - Tyagi, Suresh C
AU  - Tyagi SC
AD  - Department of Physiology and Biophysics, University of Louisville School of 
      Medicine, Louisville, KY 40292, United States.
LA  - eng
GR  - R01 HL104103/HL/NHLBI NIH HHS/United States
GR  - HL-104103/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140622
PL  - United States
TA  - Nitric Oxide
JT  - Nitric oxide : biology and chemistry
JID - 9709307
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Adenosine Triphosphate/*metabolism
MH  - Anaerobiosis
MH  - Animals
MH  - *Homocysteine
MH  - Humans
MH  - *Hydrogen Sulfide
MH  - Kidney/blood supply/physiopathology
MH  - *Kidney Diseases/metabolism/physiopathology
MH  - Mice
MH  - Rats
MH  - *Vascular Diseases/metabolism/physiopathology
PMC - PMC4156889
MID - NIHMS607768
OTO - NOTNLM
OT  - Extracellular matrix
OT  - Homocysteine
OT  - Hydrogen sulfide
OT  - Hypertension
OT  - Inflammation
OT  - Matrix metalloproteinase
OT  - Mitophagy
OT  - Renal remodeling
COIS- Conflict of interest: None
EDAT- 2014/06/26 06:00
MHDA- 2015/06/02 06:00
PMCR- 2015/09/15
CRDT- 2014/06/26 06:00
PHST- 2014/02/04 00:00 [received]
PHST- 2014/06/16 00:00 [revised]
PHST- 2014/06/17 00:00 [accepted]
PHST- 2014/06/26 06:00 [entrez]
PHST- 2014/06/26 06:00 [pubmed]
PHST- 2015/06/02 06:00 [medline]
PHST- 2015/09/15 00:00 [pmc-release]
AID - S1089-8603(14)00251-1 [pii]
AID - 10.1016/j.niox.2014.06.006 [doi]
PST - ppublish
SO  - Nitric Oxide. 2014 Sep 15;41:27-37. doi: 10.1016/j.niox.2014.06.006. Epub 2014 
      Jun 22.