PMID- 2496438
OWN - NLM
STAT- MEDLINE
DCOM- 19890526
LR  - 20190828
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 24
IP  - 3
DP  - 1989 Mar
TI  - Intracerebroventricular administration of calcitonin enhances glucose-stimulated 
      release of insulin.
PG  - 259-68
AB  - Intracerebroventricular (i.c.v.) administration of salmon calcitonin (500 ng) 
      augmented glucose-stimulated release of insulin in rats. Vagotomy increased this 
      enhancement effect of i.c.v. calcitonin significantly, whereas peripheral 
      atropine treatment did not change it. Adrenal catecholamines did not participate 
      in the centrally mediated insulinotropic effect of calcitonin since acute 
      adrenalectomy did not modify the enhancement effect of i.c.v. calcitonin. 
      Destruction of the sympathetic ganglia by neonatal treatment with 
      6-hydroxydopamine abolished the enhancement effect of i.c.v. calcitonin, which 
      suggests that the sympathetic nervous system participates in the central action 
      of calcitonin to enhance glucose-stimulated release of insulin.
FAU - Greeley, G H Jr
AU  - Greeley GH Jr
AD  - Department of Surgery, University of Texas Medical Branch, Galveston 77550.
FAU - Cooper, C W
AU  - Cooper CW
FAU - Jeng, Y J
AU  - Jeng YJ
FAU - Eldridge, J C
AU  - Eldridge JC
FAU - Thompson, J C
AU  - Thompson JC
LA  - eng
GR  - 5R37 DK 15241/DK/NIDDK NIH HHS/United States
GR  - AM 33021/AM/NIADDK NIH HHS/United States
GR  - P0I DK 35608/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Hydroxydopamines)
RN  - 0 (Insulin)
RN  - 7C0697DR9I (Atropine)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - 9007-12-9 (Calcitonin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Calcitonin/administration & dosage/*pharmacology
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Drug Synergism
MH  - Female
MH  - Ganglia, Sympathetic/physiology
MH  - Ganglionectomy
MH  - Glucose/*pharmacology
MH  - Hydroxydopamines
MH  - Injections, Intraventricular
MH  - Insulin/blood/*metabolism
MH  - Insulin Secretion
MH  - Male
MH  - Oxidopamine
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Vagotomy
EDAT- 1989/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/03/01 00:00
PHST- 1989/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/03/01 00:00 [entrez]
AID - 0167-0115(89)90222-X [pii]
AID - 10.1016/0167-0115(89)90222-x [doi]
PST - ppublish
SO  - Regul Pept. 1989 Mar;24(3):259-68. doi: 10.1016/0167-0115(89)90222-x.