PMID- 24964628
OWN - NLM
STAT- MEDLINE
DCOM- 20150616
LR  - 20181202
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 43
IP  - 3
DP  - 2014 May
TI  - [Rapid analysis of six sweeteners in wine by dispersive solid-phase extraction 
      and ultra-fast liquid chromatography coupled with tandem mass spectrometry].
PG  - 455-62
AB  - OBJECTIVE: To develop a rapid and simple qualitative and quantitative method for 
      determination of acesulfame, saccharin, cyclamate, aspartame, stevioside and 
      neotame in wine by dispersive solid-phase extraction and ultra-fast liquid 
      chromatography coupled with electrospray ionization tandem mass spectrometry 
      (dSPE-UFLC-ESI/MS/MS). METHODS: After the sample was extracted and cleaned by 
      dispersive solid-phase extraction using novel magnetic nanomaterials as 
      adsorbents, the separation was performed by UFLC and the cracking was used by the 
      optimized ESI/MS/MS conditions in a negative electrospray ionization mode. 
      Confirmatory detection was carried out by the principle of three qualitative ions 
      and the retention time. RESULTS: The interference matrix could be effectively 
      adsorbed by the novel magnetic nanomaterials. The MS/MS fragment ions were 
      reliable and steady under the suitable conditions, the cracking ways to the 
      parent ions and fragment ions were clear. Quantitative ion pairs were m/z 162 --> 
      82 for acesulfame, m/z 182 --> 42 for saccharin, m/z 178 --> 80 for cyclamate, 
      m/z 293 --> 200 for aspartame, m/z 803 --> 641 for stevioside, m/z 377 --> 200 
      for neotame. The recoveries were between 83.4% and 104.0% with the relative 
      standard deviations (RSDs) of 1.1% - 4.0%. The limits of quantification (LOQs) 
      were in the range of 0.1 - 5.0 microg/L. CONCLUSION: The established method was 
      rapid, accurate and sensitive, it is suitable for confirmation for acesulfame, 
      saccharin, cyclamate, aspartame, stevioside and neotame in wine.
FAU - Chen, Xiaohong
AU  - Chen X
FAU - Zhu, Hao
AU  - Zhu H
FAU - Zhou, Lixin
AU  - Zhou L
FAU - Zhao, Yonggang
AU  - Zhao Y
FAU - Jin, Micong
AU  - Jin M
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Cyclamates)
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Chromatography, Liquid
MH  - Cyclamates
MH  - Solid Phase Extraction
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Sweetening Agents/*analysis
MH  - *Tandem Mass Spectrometry
MH  - *Wine
EDAT- 2014/06/27 06:00
MHDA- 2015/06/17 06:00
CRDT- 2014/06/27 06:00
PHST- 2014/06/27 06:00 [entrez]
PHST- 2014/06/27 06:00 [pubmed]
PHST- 2015/06/17 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2014 May;43(3):455-62.