PMID- 2496548
OWN - NLM
STAT- MEDLINE
DCOM- 19890530
LR  - 20180216
IS  - 0001-5792 (Print)
IS  - 0001-5792 (Linking)
VI  - 81
IP  - 2
DP  - 1989
TI  - Refractory anemia terminating in acute megakaryoblastic leukemia (M7).
PG  - 104-8
AB  - A 72-year-old man with refractory anemia (RA) developed overt megakaryoblastic 
      leukemia after the course of RA with excess of blasts. The blasts were positive 
      for platelet peroxidase activity and had platelet glycoproteins (GPs) such as 
      GPIIb/IIIa and GPIIIa. The bone marrow biopsy at terminal stage disclosed marked 
      fibrosis. The nature of the megakaryoblasts was investigated. The blasts did not 
      differentiate morphologically into mature megakaryocytes with TPA addition. In 
      vitro colony assay showed the failure of colony-forming unit, megakaryocyte 
      growth in peripheral blood. The pathogenesis of myelofibrosis in our patient is 
      discussed.
FAU - Adachi, M
AU  - Adachi M
AD  - Department of Laboratory Medicine, Kobe University School of Medicine, Japan.
FAU - Ryo, R
AU  - Ryo R
FAU - Yoshida, A
AU  - Yoshida A
FAU - Yamaguchi, N
AU  - Yamaguchi N
FAU - Izumi, Y
AU  - Izumi Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (Antigens, Surface)
RN  - EC 1.11.1.- (Peroxidases)
SB  - IM
MH  - Aged
MH  - Anemia, Refractory/blood/*pathology
MH  - Antigens, Surface/analysis
MH  - Blast Crisis/ultrastructure
MH  - Blood Platelets/enzymology
MH  - Bone Marrow/pathology
MH  - Cell Transformation, Neoplastic/*pathology
MH  - Humans
MH  - Leukemia, Megakaryoblastic, Acute/blood/*pathology
MH  - Male
MH  - Peroxidases/blood
MH  - Tumor Cells, Cultured/ultrastructure
MH  - Tumor Stem Cell Assay
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1159/000205536 [doi]
PST - ppublish
SO  - Acta Haematol. 1989;81(2):104-8. doi: 10.1159/000205536.