PMID- 24965798
OWN - NLM
STAT- MEDLINE
DCOM- 20150522
LR  - 20240322
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Print)
IS  - 1018-8827 (Linking)
VI  - 24
IP  - 3
DP  - 2015 Mar
TI  - Determination of psychosis-related clinical profiles in children with autism 
      spectrum disorders using latent class analysis.
PG  - 301-7
LID - 10.1007/s00787-014-0576-1 [doi]
AB  - In children with autism spectrum disorders (ASD), high rates of idiosyncratic 
      fears and anxiety reactions and thought disorder are thought to increase the risk 
      of psychosis. The critical next step is to identify whether combinations of these 
      symptoms can be used to categorise individual patients into ASD subclasses, and 
      to test their relevance to psychosis. All patients with ASD (n = 84) admitted to 
      a specialist national inpatient unit from 2003 to 2012 were rated for the 
      presence or absence of impairment in affective regulation and anxiety (peculiar 
      phobias, panic episodes, explosive reactions to anxiety), social deficits (social 
      disinterest, avoidance or withdrawal and abnormal attachment) and thought 
      disorder (disorganised or illogical thinking, bizarre fantasies, overvalued or 
      delusional ideas). Latent class analysis of individual symptoms was conducted to 
      identify ASD classes. External validation of these classes was performed using as 
      a criterion the presence of hallucinations. Latent class analysis identified two 
      distinct classes. Bizarre fears and anxiety reactions and thought disorder 
      symptoms differentiated ASD patients into those with psychotic features (ASD-P: 
      51 %) and those without (ASD-NonP: 49 %). Hallucinations were present in 26 % of 
      the ASD-P class but only 2.4 % of the ASD-NonP. Both the ASD-P and the ASD-NonP 
      class benefited from inpatient treatment although inpatient stay was prolonged in 
      the ASD-P class. This study provides the first empirically derived classification 
      of ASD in relation to psychosis based on three underlying symptom dimensions, 
      anxiety, social deficits and thought disorder. These results can be further 
      developed by testing the reproducibility and prognostic value of the identified 
      classes.
FAU - Kyriakopoulos, Marinos
AU  - Kyriakopoulos M
AD  - Child and Adolescent Mental Health Clinical Academic Group, South London and the 
      Maudsley NHS Foundation Trust, London, UK, marinos.kyriakopoulos@kcl.ac.uk.
FAU - Stringaris, Argyris
AU  - Stringaris A
FAU - Manolesou, Sofia
AU  - Manolesou S
FAU - Radobuljac, Maja Drobnic
AU  - Radobuljac MD
FAU - Jacobs, Brian
AU  - Jacobs B
FAU - Reichenberg, Avi
AU  - Reichenberg A
FAU - Stahl, Daniel
AU  - Stahl D
FAU - Simonoff, Emily
AU  - Simonoff E
FAU - Frangou, Sophia
AU  - Frangou S
LA  - eng
GR  - 093909/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20140626
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
SB  - IM
MH  - Adolescent
MH  - Anxiety/*diagnosis/psychology
MH  - Anxiety Disorders/diagnosis
MH  - Child
MH  - Child Development Disorders, Pervasive/*classification/etiology/psychology
MH  - Cross-Sectional Studies
MH  - Delusions
MH  - Fear/psychology
MH  - Female
MH  - Hallucinations/*diagnosis/psychology
MH  - Humans
MH  - Male
MH  - Phobic Disorders
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Psychotic Disorders/complications/*diagnosis/psychology
MH  - Reproducibility of Results
PMC - PMC4224587
MID - EMS59824
OID - NLM: EMS59824
EDAT- 2014/06/27 06:00
MHDA- 2015/05/23 06:00
PMCR- 2014/06/26
CRDT- 2014/06/27 06:00
PHST- 2014/03/26 00:00 [received]
PHST- 2014/06/09 00:00 [accepted]
PHST- 2014/06/27 06:00 [entrez]
PHST- 2014/06/27 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
PHST- 2014/06/26 00:00 [pmc-release]
AID - 576 [pii]
AID - 10.1007/s00787-014-0576-1 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2015 Mar;24(3):301-7. doi: 
      10.1007/s00787-014-0576-1. Epub 2014 Jun 26.