PMID- 24967064
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140626
LR  - 20240321
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 17
IP  - 5
DP  - 2014 May
TI  - Genetic polymorphisms of glutathione-s-transferase M1 and T1 genes with risk of 
      diabetic retinopathy in Iranian population.
PG  - 351-6
AB  - OBJECTIVES: To the best of our knowledge, this is the first report on the 
      contributions of GST genetic variants to the risk of diabetic retinopathy in an 
      Iranian population. Therefore, the objective of this study was to determine 
      whether sequence variation in glutathione S-transferase gene (GSTM1 and GSTT1) is 
      associated with development of diabetic retinopathy in type 2 diabetes mellitus 
      (T2DM) Iranian patients. MATERIALS AND METHODS: A total of 605 subjects were 
      investigated in this case-control study; Study groups consisted of 201 patients 
      with diabetic retinopathy (DR), 203 subjects with no clinically significant signs 
      of DR and a group of 201 cases of healthy volunteers with no clinical evidence of 
      diabetes mellitus or any other diseases. The GSTM1 and GSTT1 were genotyped by 
      multiplex-polymerase chain reaction (multiplex-PCR) analysis in all 404 T2DM 
      patients and 201 healthy individuals served as control. RESULTS: Increased odds 
      ratio showed that GSTM1-null genotype had a moderately higher occurrence in T2DM 
      patients (OR=1.43, 95% CI=1.01-2.04; P=0.03) than in healthy individuals. 
      However, the frequency of GSTT1 genotype (OR=1.41; 95% CI=0.92-2.18; P=0.09) was 
      not significantly different comparing both groups. Although, regression analysis 
      in T2DM patients showed that GSTM1 and GSTT1 genotypes are not associated with 
      T2DM retinopathy development. CONCLUSION: Our findings suggest that GSTM1 and 
      GSTT1 genotypes might not be involved in the pathogenesis of type 2 diabetes 
      mellitus retinopathy in the Southern Iranian population. However, further 
      investigations are needed to confirm these results in other larger populations.
FAU - Moasser, Elham
AU  - Moasser E
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Azarpira, Negar
AU  - Azarpira N
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Shirazi, Babak
AU  - Shirazi B
AD  - Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Saadat, Mostafa
AU  - Saadat M
AD  - Biology Department, Faculty of Science, Shiraz University, Shiraz, Iran.
FAU - Geramizadeh, Bita
AU  - Geramizadeh B
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ; 
      Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC4069842
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Gene polymorphisms
OT  - Glutathione S-Transferase
OT  - Iranian population
EDAT- 2014/06/27 06:00
MHDA- 2014/06/27 06:01
PMCR- 2014/05/01
CRDT- 2014/06/27 06:00
PHST- 2013/08/10 00:00 [received]
PHST- 2014/01/13 00:00 [accepted]
PHST- 2014/06/27 06:00 [entrez]
PHST- 2014/06/27 06:00 [pubmed]
PHST- 2014/06/27 06:01 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - IJBMS-17-351 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2014 May;17(5):351-6.