PMID- 24967237
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140626
LR  - 20220317
IS  - 2314-405X (Print)
IS  - 2314-405X (Electronic)
IS  - 2314-405X (Linking)
VI  - 2013
DP  - 2013
TI  - Sex-Related Difference in Nitric Oxide Metabolites Levels after Nephroprotectant 
      Supplementation Administration against Cisplatin-Induced Nephrotoxicity in Wistar 
      Rat Model: The Role of Vitamin E, Erythropoietin, or N-Acetylcysteine.
PG  - 612675
LID - 10.5402/2013/612675 [doi]
LID - 612675
AB  - Background. Nitric oxide (NO) concentration in serum is altered by cisplatin 
      (CP), and NO influences CP-induced nephrotoxicity. The effect of nephroprotectant 
      agent supplementation (vitamin E, human recombinant erythropoietin (EPO), or 
      n-acetylcysteine (NAC)) on the NO metabolites levels after CP administration in 
      the two genders was determined. Methods. Sixty-four adult Wistar rats were 
      randomly divided into 10 groups. Male and female rats in different groups 
      received vehicle (saline), CP (7 mg/kg) alone, CP plus EPO (100 IU/kg), CP plus 
      vitamin E (250 mg/kg), and CP plus NAC (600 mg/kg). CP was administrated as a 
      single dose, but the supplementations were given for a period of 7 days. Results. 
      In male rats, the serum levels of total NO metabolites (NO x ) and nitrite were 
      increased significantly (P < 0.05) by CP. However, vitamin E significantly 
      reduced the serum levels of these metabolites, which was increased by 
      administration of CP (P < 0.05), and such findings were not observed for female 
      rats. The EPO or NAC did not influence NO metabolites neither in male rats nor in 
      female rats. Conclusion. Although vitamin E, EPO, and NAC are reported to be 
      nephroprotectant agents against CP-induced nephrotoxicity, only vitamin E could 
      reduce the level of all NO metabolites only in male rats.
FAU - Nematbakhsh, Mehdi
AU  - Nematbakhsh M
AUID- ORCID: 0000-0002-9565-9187
AD  - Water and Electrolytes Research Center, Isfahan University of Medical Sciences, 
      Isfahan 81745, Iran ; Department of Physiology, Isfahan University of Medical 
      Sciences, Isfahan 81745, Iran.
FAU - Pezeshki, Zahra
AU  - Pezeshki Z
AD  - Water and Electrolytes Research Center, Isfahan University of Medical Sciences, 
      Isfahan 81745, Iran.
LA  - eng
PT  - Journal Article
DEP - 20130311
PL  - United States
TA  - ISRN Nephrol
JT  - ISRN nephrology
JID - 101612036
PMC - PMC4045416
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/03/11
CRDT- 2014/06/27 06:00
PHST- 2013/01/22 00:00 [received]
PHST- 2013/02/14 00:00 [accepted]
PHST- 2014/06/27 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/03/11 00:00 [pmc-release]
AID - 10.5402/2013/612675 [doi]
PST - epublish
SO  - ISRN Nephrol. 2013 Mar 11;2013:612675. doi: 10.5402/2013/612675. eCollection 
      2013.