PMID- 24967547
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20140806
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 121
DP  - 2014 Sep 1
TI  - Model carcinogen adsorption dynamics of DNA gel.
PG  - 122-8
LID - S0927-7765(14)00283-5 [pii]
LID - 10.1016/j.colsurfb.2014.05.039 [doi]
AB  - We have derived theoretical equations describing the adsorption of carcinogen to 
      gels in an immersion medium containing carcinogens. The theory was developed for 
      a cylindrical boundary condition under the assumption of a carcinogen 
      diffusion-limited process combined with the "moving boundary picture (Furusawa et 
      al., 2007)". The time course of the adsorbed carcinogen layer thickness and that 
      of the carcinogen concentration in an immersion medium were expressed by a set of 
      scaled variables, and the asymptotic behavior in the initial stage was derived. 
      Experiments based on the theory were performed using a DNA gel sandwiched between 
      a set of coverglasses in a medium containing acridine orange (AO). The boundary 
      between the AO-adsorbed gel layer and AO-nonadsorbed gel layer was traced during 
      the immersion. The time courses of the AO-adsorbed gel layer thickness and the AO 
      concentration in the immersion medium were well explained by the theory, and the 
      number ratio of the total AO molecules to the adsorption sites in the DNA gel was 
      determined.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Tomita, Naoko
AU  - Tomita N
AD  - Department of Chemistry and Chemical Biology, Graduate School of Engineering, 
      Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
FAU - Naito, Daisuke
AU  - Naito D
AD  - Department of Chemistry and Chemical Biology, Graduate School of Engineering, 
      Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
FAU - Rokugawa, Isamu
AU  - Rokugawa I
AD  - Department of Chemistry and Chemical Biology, Graduate School of Engineering, 
      Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
FAU - Yamamoto, Takao
AU  - Yamamoto T
AD  - Department of Chemistry and Chemical Biology, Graduate School of Engineering, 
      Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
FAU - Dobashi, Toshiaki
AU  - Dobashi T
AD  - Department of Chemistry and Chemical Biology, Graduate School of Engineering, 
      Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan. Electronic address: 
      dobashi@gunma-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140605
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Carcinogens)
RN  - 0 (Gels)
RN  - 0 (Solutions)
RN  - 9007-49-2 (DNA)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*chemistry
MH  - Adsorption
MH  - Animals
MH  - Carcinogens/*chemistry
MH  - DNA/*chemistry
MH  - Gels/*chemistry
MH  - Salmon
MH  - Solutions
MH  - Time Factors
OTO - NOTNLM
OT  - Adsorption
OT  - DNA
OT  - Dynamics
OT  - Gel
OT  - Model carcinogen
EDAT- 2014/06/27 06:00
MHDA- 2015/04/15 06:00
CRDT- 2014/06/27 06:00
PHST- 2014/01/11 00:00 [received]
PHST- 2014/05/25 00:00 [revised]
PHST- 2014/05/28 00:00 [accepted]
PHST- 2014/06/27 06:00 [entrez]
PHST- 2014/06/27 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - S0927-7765(14)00283-5 [pii]
AID - 10.1016/j.colsurfb.2014.05.039 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2014 Sep 1;121:122-8. doi: 
      10.1016/j.colsurfb.2014.05.039. Epub 2014 Jun 5.