PMID- 24968246
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20221207
IS  - 1532-4281 (Electronic)
IS  - 1079-9893 (Linking)
VI  - 35
IP  - 1
DP  - 2015 Feb
TI  - Relationship between MCP-1 promoter -2518 A/G gene polymorphism (rs1024611) and 
      systemic lupus erythematosus/lupus nephritis.
PG  - 85-93
LID - 10.3109/10799893.2014.931433 [doi]
AB  - Results from the published studies on the association between monocyte 
      chemoattractant protein-1 (MCP-1) promoter -2518 A/G (rs1024611) gene 
      polymorphism and systemic lupus erythematosus (SLE)/lupus nephritis (LN) are 
      still conflicting. This meta-analysis was performed to evaluate the relationship 
      between MCP-1 A/G gene polymorphism and SLE/LN and to explore whether MCP-1 A 
      allele, AA genotype or GG genotype could become a predictive marker for SLE/LN 
      risk. Association studies were identified from the databases of PubMed, Embase, 
      Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 
      January 2014, and eligible investigations were synthesized using meta-analysis 
      method. Results were expressed with odds ratios (OR) for dichotomous data, and 
      95% confidence intervals (CI) were also calculated. Sixteen investigations were 
      identified for the analysis of association between MCP-1 A/G gene polymorphism 
      and SLE, consisting of 2425 patients with SLE and 2567 controls. In the overall 
      populations, Asians, Caucasian population, the association between MCP-1 A/G gene 
      polymorphism and SLE susceptibility was not found. Interestingly, a trend toward 
      an association between A allele/AA genotype and LN risk was observed in overall 
      populations, although there was no statistical difference. However, this 
      meta-analysis indicated that AA genotype was associated with LN risk in 
      Caucasians (OR = 0.71; 95% CI: 0.54-0.93; p = 0.01). In conclusion, our results 
      indicate that AA homozygous might be a significant genetic molecular marker to 
      predict the SLE patients developing into LN in Caucasians. However, more 
      investigations are required to further clarify this association.
FAU - Zhou, Tian-Biao
AU  - Zhou TB
AD  - Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , 
      Guangzhou , China.
FAU - Jiang, Zong-Pei
AU  - Jiang ZP
FAU - Liang, Meng-Jun
AU  - Liang MJ
FAU - Huang, Ya-Juan
AU  - Huang YJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140626
PL  - England
TA  - J Recept Signal Transduct Res
JT  - Journal of receptor and signal transduction research
JID - 9509432
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - China
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Homozygote
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics/pathology
MH  - Lupus Nephritis/*genetics/pathology
MH  - Polymorphism, Single Nucleotide
MH  - White People
OTO - NOTNLM
OT  - A/G gene polymorphism
OT  - lupus nephritis
OT  - meta-analysis
OT  - monocyte chemoattractant protein-1
OT  - systemic lupus erythematosus
EDAT- 2014/06/27 06:00
MHDA- 2016/02/09 06:00
CRDT- 2014/06/27 06:00
PHST- 2014/06/27 06:00 [entrez]
PHST- 2014/06/27 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - 10.3109/10799893.2014.931433 [doi]
PST - ppublish
SO  - J Recept Signal Transduct Res. 2015 Feb;35(1):85-93. doi: 
      10.3109/10799893.2014.931433. Epub 2014 Jun 26.